Literature DB >> 28658833

Insulin (Technique) Induced Hypoglycaemia.

Adlyne Reena Asirvatham1, Shriraam Mahadevan2, Balasubramaniam Sathish Kumar3, Srinivas Devaganipalli Nrusimha4, Thiagarajan Radhakrishnan Vadivel4.   

Abstract

The most common side effect of insulin therapy is hypoglycaemia apart from weight gain. It occurs commonly due to insulin overdose, faulty injection site, technique and meal-insulin mismatch. In lean individuals even the needle size can be a contributing factor to hypoglycaemia. Here we report a case who presented with recurrent episodes of hypoglycaemia due to a combination of wrong insulin site, technique as well as needle size. On examination, he was found to have spotted dermopathy on his forearms (insulin injection site) which was consistent with intradermal insulin administration. Recently, insulin infusion through intradermal route has been found to reach the systemic circulation faster than even the conventional subcutaneous injection. This case emphasizes that hypoglycaemias can occur due to less common causes. It warrants a good clinical examination and patient education.

Entities:  

Keywords:  Hypoglycaemia; Intradermal insulin; Spotted dermopathy

Year:  2017        PMID: 28658833      PMCID: PMC5483735          DOI: 10.7860/JCDR/2017/26203.9809

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  9 in total

1.  Systematic inspection of insulin injection sites for local complications related to incorrect injection technique.

Authors:  B Seyoum; J Abdulkadir
Journal:  Trop Doct       Date:  1996-10       Impact factor: 0.731

2.  Does needle size matter?

Authors:  Harvinder S Gill; Mark R Prausnitz
Journal:  J Diabetes Sci Technol       Date:  2007-09

Review 3.  Microneedle delivery: clinical studies and emerging medical applications.

Authors:  Ronald J Pettis; Alfred J Harvey
Journal:  Ther Deliv       Date:  2012-03

4.  National estimates of insulin-related hypoglycemia and errors leading to emergency department visits and hospitalizations.

Authors:  Andrew I Geller; Nadine Shehab; Maribeth C Lovegrove; Scott R Kegler; Kelly N Weidenbach; Gina J Ryan; Daniel S Budnitz
Journal:  JAMA Intern Med       Date:  2014-05       Impact factor: 21.873

5.  Intradermal insulin infusion achieves faster insulin action than subcutaneous infusion for 3-day wear.

Authors:  Christopher James Rini; Elaine McVey; Diane Sutter; Stephen Keith; Heinz-Joerg Kurth; Leszek Nosek; Christoph Kapitza; Kerstin Rebrin; Laurence Hirsch; Ronald J Pettis
Journal:  Drug Deliv Transl Res       Date:  2015-08       Impact factor: 4.617

6.  Incorrect Insulin Administration: A Problem That Warrants Attention.

Authors:  Paula M Trief; Donald Cibula; Elaine Rodriguez; Bridget Akel; Ruth S Weinstock
Journal:  Clin Diabetes       Date:  2016-01

7.  Correlates of insulin injection omission.

Authors:  Mark Peyrot; Richard R Rubin; Davida F Kruger; Luther B Travis
Journal:  Diabetes Care       Date:  2010-02       Impact factor: 19.112

8.  Faulty Injection Technique: A Preventable But Often Overlooked Factor in Insulin Allergy.

Authors:  Partha Pratim Chakraborty; Sugata Narayan Biswas; Shinjan Patra
Journal:  Diabetes Ther       Date:  2016-02-03       Impact factor: 2.945

9.  Improved Insulin Pharmacokinetics Using a Novel Microneedle Device for Intradermal Delivery in Patients with Type 2 Diabetes.

Authors:  Efrat Kochba; Yotam Levin; Itamar Raz; Avivit Cahn
Journal:  Diabetes Technol Ther       Date:  2016-08-08       Impact factor: 6.118

  9 in total
  1 in total

Review 1.  The Utility of Exosomes in Diagnosis and Therapy of Diabetes Mellitus and Associated Complications.

Authors:  Yaoxiang Sun; Qing Tao; Xueqin Wu; Ling Zhang; Qi Liu; Lei Wang
Journal:  Front Endocrinol (Lausanne)       Date:  2021-10-26       Impact factor: 5.555

  1 in total

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