Literature DB >> 28658761

Ebola Vaccine: How Far are we?

Rajani Sharma1, Ketki Jangid1.   

Abstract

Ebola viruses have been identified as an emerging threat as it causes severe haemorrhagic fever in human with mortality rates ranging from 50 to 90%. In addition to being a global health concern, the virus also is considered a potential biological threat agent. As for now, no licensed vaccine is available for pre or post exposure treatment. Recent epidemic of this disease in South Africa has led to concern towards development of an effective vaccine on a priority basis. This review is an attempt to look upon current progress in the development of Ebola virus vaccines and highlights strategies that have the greatest potential for commercial development.

Entities:  

Keywords:  Clinical trial; Ebola virus; Haemorrhagic fever

Year:  2017        PMID: 28658761      PMCID: PMC5483663          DOI: 10.7860/JCDR/2017/22184.9863

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  40 in total

1.  Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury.

Authors:  Z Y Yang; H J Duckers; N J Sullivan; A Sanchez; E G Nabel; G J Nabel
Journal:  Nat Med       Date:  2000-08       Impact factor: 53.440

2.  Positive Phase II interim data on AE37 cancer vaccine released.

Authors: 
Journal:  Hum Vaccin Immunother       Date:  2012-02-01       Impact factor: 3.452

3.  Multivesicular bodies as a platform for formation of the Marburg virus envelope.

Authors:  Larissa Kolesnikova; Beate Berghöfer; Sandra Bamberg; Stephan Becker
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

Review 4.  Filovirus diseases.

Authors:  C J Peters; A S Khan
Journal:  Curr Top Microbiol Immunol       Date:  1999       Impact factor: 4.291

5.  Descriptive analysis of Ebola virus proteins.

Authors:  L H Elliott; M P Kiley; J B McCormick
Journal:  Virology       Date:  1985-11       Impact factor: 3.616

6.  Inactivated Marburg virus elicits a nonprotective immune response in Rhesus monkeys.

Authors:  G M Ignatyev; A P Agafonov; M A Streltsova; E A Kashentseva
Journal:  J Biotechnol       Date:  1996-01-26       Impact factor: 3.307

7.  Development of a preventive vaccine for Ebola virus infection in primates.

Authors:  N J Sullivan; A Sanchez; P E Rollin; Z Y Yang; G J Nabel
Journal:  Nature       Date:  2000-11-30       Impact factor: 49.962

8.  DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge.

Authors:  L Vanderzanden; M Bray; D Fuller; T Roberts; D Custer; K Spik; P Jahrling; J Huggins; A Schmaljohn; C Schmaljohn
Journal:  Virology       Date:  1998-06-20       Impact factor: 3.616

9.  Evaluation in nonhuman primates of vaccines against Ebola virus.

Authors:  Thomas W Geisbert; Peter Pushko; Kevin Anderson; Jonathan Smith; Kelly J Davis; Peter B Jahrling
Journal:  Emerg Infect Dis       Date:  2002-05       Impact factor: 6.883

10.  Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs.

Authors:  Nancy J Sullivan; Thomas W Geisbert; Joan B Geisbert; Devon J Shedlock; Ling Xu; Laurie Lamoreaux; Jerome H H V Custers; Paul M Popernack; Zhi-Yong Yang; Maria G Pau; Mario Roederer; Richard A Koup; Jaap Goudsmit; Peter B Jahrling; Gary J Nabel
Journal:  PLoS Med       Date:  2006-05-16       Impact factor: 11.069

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  2 in total

1.  The molecular tweezer CLR01 inhibits Ebola and Zika virus infection.

Authors:  Annika E Röcker; Janis A Müller; Erik Dietzel; Mirja Harms; Franziska Krüger; Christian Heid; Andrea Sowislok; Camilla Frich Riber; Alexandra Kupke; Sina Lippold; Jens von Einem; Judith Beer; Bernd Knöll; Stephan Becker; Jonas Schmidt-Chanasit; Markus Otto; Olli Vapalahti; Alexander N Zelikin; Gal Bitan; Thomas Schrader; Jan Münch
Journal:  Antiviral Res       Date:  2018-02-08       Impact factor: 5.970

Review 2.  Dendritic Cells/Macrophages-Targeting Feature of Ebola Glycoprotein and its Potential as Immunological Facilitator for Antiviral Vaccine Approach.

Authors:  Titus Abiola Olukitibi; Zhujun Ao; Mona Mahmoudi; Gary A Kobinger; Xiaojian Yao
Journal:  Microorganisms       Date:  2019-09-29
  2 in total

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