Literature DB >> 28658642

Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers.

Duy Luong1, Prashant Kesharwani2, Hashem O Alsaab3, Samaresh Sau1, Subhash Padhye4, Fazlul H Sarkar5, Arun K Iyer6.   

Abstract

The current study utilizes folic acid conjugated poly(styrene-co-maleic anhydride) block copolymer (FA-SMA) to enhance the solubility of a hydrophobic but very potent synthetic curcumin-difluorinated (CDF) analog and its targeted delivery to folate receptor-alpha overexpressing cancers. The nanomicelles showed high aqueous solubility. Importantly, the encapsulation of CDF in nanomicelles resulted in high photo-stability of the otherwise photo-labile drug. When the nanomicelles were tested in folate-receptor overexpressing ovarian and cervical cancer cells they exhibited high anticancer activity causing significant cell population to undergo apoptosis due to upregulation of tumor suppressor phosphatase and tensin homolog (PTEN) and inhibition of nuclear factor kappa-B (NFκB), which further confirmed the targeting ability and anticancer potentials of folate-targeted formulations.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cervical cancer; Curcumin difluorinated (CDF); Flavonoid analog; Folate receptor-alpha targeting; Folic acid; Ovarian cancer; Polymeric micelles; Targeted drug delivery

Mesh：

Substances：

Year:  2017        PMID： 28658642      PMCID： PMC5560501          DOI： 10.1016/j.colsurfb.2017.06.025

Source DB:  PubMed          Journal:  Colloids Surf B Biointerfaces        ISSN： 0927-7765            Impact factor:   5.268


  54 in total

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Journal:  J Biol Chem       Date:  2002-05-01       Impact factor: 5.157

2.  Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation.

Authors:  Arun K Iyer; Khaled Greish; Takahiro Seki; Shoko Okazaki; Jun Fang; Keizo Takeshita; Hiroshi Maeda
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Journal:  Biomacromolecules       Date:  2017-03-09       Impact factor: 6.988

4.  Assessment of penetration potential of pH responsive double walled biodegradable nanogels coated with eucalyptus oil for the controlled delivery of 5-fluorouracil: In vitro and ex vivo studies.

Authors:  Prashant Sahu; Sushil K Kashaw; Sanyog Jain; Samaresh Sau; Arun K Iyer
Journal:  J Control Release       Date:  2017-03-18       Impact factor: 9.776

Review 5.  The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?

Authors:  Linda E Kelemen
Journal:  Int J Cancer       Date:  2006-07-15       Impact factor: 7.396

Review 6.  Principles in the design of ligand-targeted cancer therapeutics and imaging agents.

Authors:  Madduri Srinivasarao; Chris V Galliford; Philip S Low
Journal:  Nat Rev Drug Discov       Date:  2015-02-20       Impact factor: 84.694

7.  PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

Authors:  Yoichi Nagata; Keng-Hsueh Lan; Xiaoyan Zhou; Ming Tan; Francisco J Esteva; Aysegul A Sahin; Kristine S Klos; Ping Li; Brett P Monia; Nina T Nguyen; Gabriel N Hortobagyi; Mien-Chie Hung; Dihua Yu
Journal:  Cancer Cell       Date:  2004-08       Impact factor: 31.743

Review 8.  Nanocarriers as an emerging platform for cancer therapy.

Authors:  Dan Peer; Jeffrey M Karp; Seungpyo Hong; Omid C Farokhzad; Rimona Margalit; Robert Langer
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Authors:  Xiaoqian Yang; Arun K Iyer; Amit Singh; Edwin Choy; Francis J Hornicek; Mansoor M Amiji; Zhenfeng Duan
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10.  Folate Decorated Nanomicelles Loaded with a Potent Curcumin Analogue for Targeting Retinoblastoma.

Authors:  Hashem Alsaab; Rami M Alzhrani; Prashant Kesharwani; Samaresh Sau; Sai Hs Boddu; Arun K Iyer
Journal:  Pharmaceutics       Date:  2017-04-18       Impact factor: 6.321
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  21 in total

Review 1.  Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent evaluation.

Authors:  Ghazal Nabil; Ketki Bhise; Samaresh Sau; Mohamed Atef; Hossny A El-Banna; Arun K Iyer
Journal:  Drug Discov Today       Date:  2018-08-16       Impact factor: 7.851

2.  Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells.

Authors:  Maryam Ghaffari; Gholamreza Dehghan; Behzad Baradaran; Amir Zarebkohan; Behzad Mansoori; Jafar Soleymani; Jafar Ezzati Nazhad Dolatabadi; Michael R Hamblin
Journal:  Colloids Surf B Biointerfaces       Date:  2019-12-27       Impact factor: 5.268

3.  CD44 directed nanomicellar payload delivery platform for selective anticancer effect and tumor specific imaging of triple negative breast cancer.

Authors:  Zhaoxian Wang; Samaresh Sau; Hashem O Alsaab; Arun K Iyer
Journal:  Nanomedicine       Date:  2018-04-17       Impact factor: 5.307

4.  Tumor hypoxia directed multimodal nanotherapy for overcoming drug resistance in renal cell carcinoma and reprogramming macrophages.

Authors:  Hashem O Alsaab; Samaresh Sau; Rami M Alzhrani; Vino T Cheriyan; Lisa A Polin; Ulka Vaishampayan; Arun K Rishi; Arun K Iyer
Journal:  Biomaterials       Date:  2018-08-30       Impact factor: 12.479

Review 5.  Multifunctional nanoparticles for cancer immunotherapy: A groundbreaking approach for reprogramming malfunctioned tumor environment.

Authors:  Samaresh Sau; Hashem O Alsaab; Ketki Bhise; Rami Alzhrani; Ghazal Nabil; Arun K Iyer
Journal:  J Control Release       Date:  2018-01-31       Impact factor: 9.776

Review 6.  A tumor multicomponent targeting chemoimmune drug delivery system for reprograming the tumor microenvironment and personalized cancer therapy.

Authors:  Samaresh Sau; Katyayani Tatiparti; Hashem O Alsaab; Sushil K Kashaw; Arun K Iyer
Journal:  Drug Discov Today       Date:  2018-03-15       Impact factor: 7.851

7.  ENO1 monoclonal antibody inhibits invasion, proliferation and clone formation of cervical cancer cells.

Authors:  Yuanfeng Gou; Fei Li; Xiaqin Huo; Chunyan Hao; Xiaojuan Yang; Yaping Pei; Na Li; Huiling Liu; Bingdong Zhu
Journal:  Am J Cancer Res       Date:  2021-05-15       Impact factor: 6.166

8.  In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles.

Authors:  Ting Qiu; Yintao Lan; Zuwu Wei; Yanfen Zhang; Yanping Lin; Chenggong Tu; Guangjuan Mao; Lingmin Zhang; Bin Yang; Jian Zhang
Journal:  Int J Nanomedicine       Date:  2021-04-15

9.  Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery.

Authors:  Nina Wijiani; Dewi Isadiartuti; M Agus Syamsur Rijal; Helmy Yusuf
Journal:  Int J Nanomedicine       Date:  2020-03-16

10.  A Novel Folic Acid Receptor-Targeted Drug Delivery System Based on Curcumin-Loaded β-Cyclodextrin Nanoparticles for Cancer Treatment.

Authors:  Weiyong Hong; Fangyuan Guo; Nan Yu; Sanjun Ying; Bang Lou; Jiangqing Wu; Ying Gao; Xugang Ji; Haiying Wang; Aiqin Li; Guoping Wang; Gensheng Yang
Journal:  Drug Des Devel Ther       Date:  2021-06-30       Impact factor: 4.162
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