Literature DB >> 28658594

Targeting protein localization for anti-infective therapy.

J Andrew Alspaugh1.   

Abstract

Keywords:  Aspergillus; Ras; antifungal therapy; farnesyltransferase; mycosis; prenylation

Mesh：

Substances：

Year:  2017        PMID： 28658594      PMCID： PMC5711423          DOI： 10.1080/21505594.2017.1342921

Source DB:  PubMed          Journal:  Virulence        ISSN： 2150-5594            Impact factor:   5.882


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  17 in total

1.  Geranylgeranyltransferase I of Candida albicans: null mutants or enzyme inhibitors produce unexpected phenotypes.

Authors:  R Kelly; D Card; E Register; P Mazur; T Kelly; K I Tanaka; J Onishi; J M Williamson; H Fan; T Satoh; M Kurtz
Journal:  J Bacteriol       Date:  2000-02       Impact factor: 3.490

Review 2.  Geranylgeranyltransferase I as a target for anti-cancer drugs.

Authors:  Mark R Philips; Adrienne D Cox
Journal:  J Clin Invest       Date:  2007-05       Impact factor: 14.808

Review 3.  Control of Ras-mediated signaling in Aspergillus fumigatus.

Authors:  Tiffany S Norton; Jarrod R Fortwendel
Journal:  Mycopathologia       Date:  2014-06-22       Impact factor: 2.574

Review 4.  Protein prenyltransferases.

Authors:  P J Casey; M C Seabra
Journal:  J Biol Chem       Date:  1996-03-08       Impact factor: 5.157

5.  A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus.

Authors:  Jarrod R Fortwendel; Wei Zhao; Ruchi Bhabhra; Steven Park; David S Perlin; David S Askew; Judith C Rhodes
Journal:  Eukaryot Cell       Date:  2005-12

6.  Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development.

Authors:  Jarrod R Fortwendel; John C Panepinto; Amy E Seitz; David S Askew; Judith C Rhodes
Journal:  Fungal Genet Biol       Date:  2004-02       Impact factor: 3.495

7.  Aspergillus fumigatus RasA regulates asexual development and cell wall integrity.

Authors:  Jarrod R Fortwendel; Kevin K Fuller; Timothy J Stephens; W Clark Bacon; David S Askew; Judith C Rhodes
Journal:  Eukaryot Cell       Date:  2008-07-07

8.  A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

Authors:  L Sepp-Lorenzino; Z Ma; E Rands; N E Kohl; J B Gibbs; A Oliff; N Rosen
Journal:  Cancer Res       Date:  1995-11-15       Impact factor: 12.701

9.  Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.

Authors:  Mark F Mabanglo; Michael A Hast; Nathan B Lubock; Homme W Hellinga; Lorena S Beese
Journal:  Protein Sci       Date:  2014-01-31       Impact factor: 6.725

10.  Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus.

Authors:  Jarrod R Fortwendel; Praveen R Juvvadi; Luise E Rogg; Yohannes G Asfaw; Kimberlie A Burns; Scott H Randell; William J Steinbach
Journal:  Eukaryot Cell       Date:  2012-05-04
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  1 in total

1.  Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi.

Authors:  Ana Camila Oliveira Souza; Qusai Al Abdallah; Kaci DeJarnette; Adela Martin-Vicente; Ashley V Nywening; Christian DeJarnette; Emily A Sansevere; Wenbo Ge; Glen E Palmer; Jarrod R Fortwendel
Journal:  Virulence       Date:  2019-12       Impact factor: 5.882
  1 in total

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