Literature DB >> 28656983

Transposase-driven rearrangements in human tumors.

Stephen C Mack1, Hiromichi Suzuki2, Michael D Taylor2.   

Abstract

A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification.

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Year:  2017        PMID： 28656983     DOI： 10.1038/ng.3908

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  10 in total

1.  Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.

Authors:  Jan J Molenaar; Jan Koster; Danny A Zwijnenburg; Peter van Sluis; Linda J Valentijn; Ida van der Ploeg; Mohamed Hamdi; Johan van Nes; Bart A Westerman; Jennemiek van Arkel; Marli E Ebus; Franciska Haneveld; Arjan Lakeman; Linda Schild; Piet Molenaar; Peter Stroeken; Max M van Noesel; Ingrid Ora; Evan E Santo; Huib N Caron; Ellen M Westerhout; Rogier Versteeg
Journal:  Nature       Date:  2012-02-22       Impact factor: 49.962

2.  Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Authors:  Paul A Northcott; Catherine Lee; Thomas Zichner; Adrian M Stütz; Serap Erkek; Daisuke Kawauchi; David J H Shih; Volker Hovestadt; Marc Zapatka; Dominik Sturm; David T W Jones; Marcel Kool; Marc Remke; Florence M G Cavalli; Scott Zuyderduyn; Gary D Bader; Scott VandenBerg; Lourdes Adriana Esparza; Marina Ryzhova; Wei Wang; Andrea Wittmann; Sebastian Stark; Laura Sieber; Huriye Seker-Cin; Linda Linke; Fabian Kratochwil; Natalie Jäger; Ivo Buchhalter; Charles D Imbusch; Gideon Zipprich; Benjamin Raeder; Sabine Schmidt; Nicolle Diessl; Stephan Wolf; Stefan Wiemann; Benedikt Brors; Chris Lawerenz; Jürgen Eils; Hans-Jörg Warnatz; Thomas Risch; Marie-Laure Yaspo; Ursula D Weber; Cynthia C Bartholomae; Christof von Kalle; Eszter Turányi; Peter Hauser; Emma Sanden; Anna Darabi; Peter Siesjö; Jaroslav Sterba; Karel Zitterbart; David Sumerauer; Peter van Sluis; Rogier Versteeg; Richard Volckmann; Jan Koster; Martin U Schuhmann; Martin Ebinger; H Leighton Grimes; Giles W Robinson; Amar Gajjar; Martin Mynarek; Katja von Hoff; Stefan Rutkowski; Torsten Pietsch; Wolfram Scheurlen; Jörg Felsberg; Guido Reifenberger; Andreas E Kulozik; Andreas von Deimling; Olaf Witt; Roland Eils; Richard J Gilbertson; Andrey Korshunov; Michael D Taylor; Peter Lichter; Jan O Korbel; Robert J Wechsler-Reya; Stefan M Pfister
Journal:  Nature       Date:  2014-06-22       Impact factor: 49.962

3.  Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.

Authors:  S C Mack; H Witt; R M Piro; L Gu; S Zuyderduyn; A M Stütz; X Wang; M Gallo; L Garzia; K Zayne; X Zhang; V Ramaswamy; N Jäger; D T W Jones; M Sill; T J Pugh; M Ryzhova; K M Wani; D J H Shih; R Head; M Remke; S D Bailey; T Zichner; C C Faria; M Barszczyk; S Stark; H Seker-Cin; S Hutter; P Johann; S Bender; V Hovestadt; T Tzaridis; A M Dubuc; P A Northcott; J Peacock; K C Bertrand; S Agnihotri; F M G Cavalli; I Clarke; K Nethery-Brokx; C L Creasy; S K Verma; J Koster; X Wu; Y Yao; T Milde; P Sin-Chan; J Zuccaro; L Lau; S Pereira; P Castelo-Branco; M Hirst; M A Marra; S S Roberts; D Fults; L Massimi; Y J Cho; T Van Meter; W Grajkowska; B Lach; A E Kulozik; A von Deimling; O Witt; S W Scherer; X Fan; K M Muraszko; M Kool; S L Pomeroy; N Gupta; J Phillips; A Huang; U Tabori; C Hawkins; D Malkin; P N Kongkham; W A Weiss; N Jabado; J T Rutka; E Bouffet; J O Korbel; M Lupien; K D Aldape; G D Bader; R Eils; P Lichter; P B Dirks; S M Pfister; A Korshunov; M D Taylor
Journal:  Nature       Date:  2014-02-19       Impact factor: 49.962

4.  Local sequence assembly reveals a high-resolution profile of somatic structural variations in 97 cancer genomes.

Authors:  Jiali Zhuang; Zhiping Weng
Journal:  Nucleic Acids Res       Date:  2015-08-17       Impact factor: 16.971

5.  Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways.

Authors:  Hye-Jung E Chun; Emilia L Lim; Alireza Heravi-Moussavi; Saeed Saberi; Karen L Mungall; Mikhail Bilenky; Annaick Carles; Kane Tse; Inna Shlafman; Kelsey Zhu; Jenny Q Qian; Diana L Palmquist; An He; William Long; Rodrigo Goya; Michelle Ng; Veronique G LeBlanc; Erin Pleasance; Nina Thiessen; Tina Wong; Eric Chuah; Yong-Jun Zhao; Jacquie E Schein; Daniela S Gerhard; Michael D Taylor; Andrew J Mungall; Richard A Moore; Yussanne Ma; Steven J M Jones; Elizabeth J Perlman; Martin Hirst; Marco A Marra
Journal:  Cancer Cell       Date:  2016-03-14       Impact factor: 31.743

6.  Highly recurrent TERT promoter mutations in human melanoma.

Authors:  Franklin W Huang; Eran Hodis; Mary Jue Xu; Gregory V Kryukov; Lynda Chin; Levi A Garraway
Journal:  Science       Date:  2013-01-24       Impact factor: 47.728

7.  Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:  Paul A Northcott; David J H Shih; John Peacock; Livia Garzia; A Sorana Morrissy; Thomas Zichner; Adrian M Stütz; Andrey Korshunov; Jüri Reimand; Steven E Schumacher; Rameen Beroukhim; David W Ellison; Christian R Marshall; Anath C Lionel; Stephen Mack; Adrian Dubuc; Yuan Yao; Vijay Ramaswamy; Betty Luu; Adi Rolider; Florence M G Cavalli; Xin Wang; Marc Remke; Xiaochong Wu; Readman Y B Chiu; Andy Chu; Eric Chuah; Richard D Corbett; Gemma R Hoad; Shaun D Jackman; Yisu Li; Allan Lo; Karen L Mungall; Ka Ming Nip; Jenny Q Qian; Anthony G J Raymond; Nina T Thiessen; Richard J Varhol; Inanc Birol; Richard A Moore; Andrew J Mungall; Robert Holt; Daisuke Kawauchi; Martine F Roussel; Marcel Kool; David T W Jones; Hendrick Witt; Africa Fernandez-L; Anna M Kenney; Robert J Wechsler-Reya; Peter Dirks; Tzvi Aviv; Wieslawa A Grajkowska; Marta Perek-Polnik; Christine C Haberler; Olivier Delattre; Stéphanie S Reynaud; François F Doz; Sarah S Pernet-Fattet; Byung-Kyu Cho; Seung-Ki Kim; Kyu-Chang Wang; Wolfram Scheurlen; Charles G Eberhart; Michelle Fèvre-Montange; Anne Jouvet; Ian F Pollack; Xing Fan; Karin M Muraszko; G Yancey Gillespie; Concezio Di Rocco; Luca Massimi; Erna M C Michiels; Nanne K Kloosterhof; Pim J French; Johan M Kros; James M Olson; Richard G Ellenbogen; Karel Zitterbart; Leos Kren; Reid C Thompson; Michael K Cooper; Boleslaw Lach; Roger E McLendon; Darell D Bigner; Adam Fontebasso; Steffen Albrecht; Nada Jabado; Janet C Lindsey; Simon Bailey; Nalin Gupta; William A Weiss; László Bognár; Almos Klekner; Timothy E Van Meter; Toshihiro Kumabe; Teiji Tominaga; Samer K Elbabaa; Jeffrey R Leonard; Joshua B Rubin; Linda M Liau; Erwin G Van Meir; Maryam Fouladi; Hideo Nakamura; Giuseppe Cinalli; Miklós Garami; Peter Hauser; Ali G Saad; Achille Iolascon; Shin Jung; Carlos G Carlotti; Rajeev Vibhakar; Young Shin Ra; Shenandoah Robinson; Massimo Zollo; Claudia C Faria; Jennifer A Chan; Michael L Levy; Poul H B Sorensen; Matthew Meyerson; Scott L Pomeroy; Yoon-Jae Cho; Gary D Bader; Uri Tabori; Cynthia E Hawkins; Eric Bouffet; Stephen W Scherer; James T Rutka; David Malkin; Steven C Clifford; Steven J M Jones; Jan O Korbel; Stefan M Pfister; Marco A Marra; Michael D Taylor
Journal:  Nature       Date:  2012-08-02       Impact factor: 49.962

8.  A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.

Authors:  Ryan S Lee; Chip Stewart; Scott L Carter; Lauren Ambrogio; Kristian Cibulskis; Carrie Sougnez; Michael S Lawrence; Daniel Auclair; Jaume Mora; Todd R Golub; Jaclyn A Biegel; Gad Getz; Charles W M Roberts
Journal:  J Clin Invest       Date:  2012-07-17       Impact factor: 14.808

9.  Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads.

Authors:  Valentí Moncunill; Santi Gonzalez; Sílvia Beà; Lise O Andrieux; Itziar Salaverria; Cristina Royo; Laura Martinez; Montserrat Puiggròs; Maia Segura-Wang; Adrian M Stütz; Alba Navarro; Romina Royo; Josep L Gelpí; Ivo G Gut; Carlos López-Otín; Modesto Orozco; Jan O Korbel; Elias Campo; Xose S Puente; David Torrents
Journal:  Nat Biotechnol       Date:  2014-10-26       Impact factor: 54.908

10.  PGBD5 promotes site-specific oncogenic mutations in human tumors.

Authors:  Anton G Henssen; Richard Koche; Jiali Zhuang; Eileen Jiang; Casie Reed; Amy Eisenberg; Eric Still; Ian C MacArthur; Elias Rodríguez-Fos; Santiago Gonzalez; Montserrat Puiggròs; Andrew N Blackford; Christopher E Mason; Elisa de Stanchina; Mithat Gönen; Anne-Katrin Emde; Minita Shah; Kanika Arora; Catherine Reeves; Nicholas D Socci; Elizabeth Perlman; Cristina R Antonescu; Charles W M Roberts; Hanno Steen; Elizabeth Mullen; Stephen P Jackson; David Torrents; Zhiping Weng; Scott A Armstrong; Alex Kentsis
Journal:  Nat Genet       Date:  2017-05-15       Impact factor: 38.330
  10 in total

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