Literature DB >> 28653127

A synthesis of oxo-thioxo[3.3.3]propellanes from dithiocarbamates and ninhydrin-malononitrile adduct.

Issa Yavari1, Aliyeh Khajeh-Khezri2.   

Abstract

An efficient method for the synthesis of oxo-thioxo[3.3.3]propellanes via reaction of dithiocarbamates, generated from primary amines and carbon disulfide, with the Knoevenagel adduct resulting from ninhydrin and malononitrile in [Formula: see text] at room temperature is described. These transformations are highlighted by their chemo- and regioselectivity, lack of activator or metal promoters, inert atmosphere, and formation of four new bonds in one operation.

Entities:  

Keywords:  Dithiocarbamate; MCR; Malononitrile; Ninhydrin; Oxo-thioxo[3.3.3]propellane

Mesh：

Substances：

Year:  2017        PMID： 28653127     DOI： 10.1007/s11030-017-9761-8

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


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  2 in total

1.  One-pot, sequential four-component synthesis of novel heterocyclic [3.3.3] propellane derivatives at room temperature.

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2.  Design and synthesis of C 3-symmetric molecules bearing propellane moieties via cyclotrimerization and a ring-closing metathesis sequence.

Authors:  Sambasivarao Kotha; Saidulu Todeti; Vikas R Aswar
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