Melanie A Ruffner1, Jonathan M Spergel2,3. 1. The Children's Hospital of Philadelphia, Division of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA. 2. The Children's Hospital of Philadelphia, Division of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA. spergel@email.chop.edu. 3. The Children's Hospital of Philadelphia, Division of Allergy and Immunology, Buerger Center for Advanced Pediatric Care, Sixth Floor, 3500 Civic Center Boulevard, Philadelphia, PA, 19104, USA. spergel@email.chop.edu.
Abstract
PURPOSE OF REVIEW: EoE is a significant cause of gastrointestinal morbidity affecting 1:2000. Patients with EoE typically have multiple atopic comorbidities, and additionally, many patients with EoE can be controlled well with elimination diets. The purpose of this review is to summarize the care of pediatric eosinophilic esophagitis patients. RECENT FINDINGS: EoE represents a distinct clinical syndrome which is characterized by esophageal dysfunction and eosinophil-predominant inflammation of the esophageal mucosa. Patients with EoE can present with varying symptoms depending on their age; in this review, we review the presenting features of eosinophilic esophagitis in children as well as a diagnostic algorithm for EoE. The mucosal inflammation in EoE is driven by exposure to food antigens in many patients with EoE. Therefore, for the majority of patients, the mainstays of treatment remain food elimination diets or swallowed steroids. This review summarizes the diagnostic approach to eosinophilic esophagitis (EoE) in pediatric patients, focusing on the importance of accurate diagnosis and selection of appropriate therapy.
PURPOSE OF REVIEW: EoE is a significant cause of gastrointestinal morbidity affecting 1:2000. Patients with EoE typically have multiple atopic comorbidities, and additionally, many patients with EoE can be controlled well with elimination diets. The purpose of this review is to summarize the care of pediatric eosinophilic esophagitispatients. RECENT FINDINGS: EoE represents a distinct clinical syndrome which is characterized by esophageal dysfunction and eosinophil-predominant inflammation of the esophageal mucosa. Patients with EoE can present with varying symptoms depending on their age; in this review, we review the presenting features of eosinophilic esophagitis in children as well as a diagnostic algorithm for EoE. The mucosal inflammation in EoE is driven by exposure to food antigens in many patients with EoE. Therefore, for the majority of patients, the mainstays of treatment remain food elimination diets or swallowed steroids. This review summarizes the diagnostic approach to eosinophilic esophagitis (EoE) in pediatric patients, focusing on the importance of accurate diagnosis and selection of appropriate therapy.
Authors: Kristina Allen-Brady; Rafael Firszt; John C Fang; Jathine Wong; Ken R Smith; Kathryn A Peterson Journal: J Allergy Clin Immunol Date: 2017-02-10 Impact factor: 10.793
Authors: S Jyonouchi; C L Smith; F Saretta; V Abraham; K R Ruymann; P Modayur-Chandramouleeswaran; M-L Wang; J M Spergel; A Cianferoni Journal: Clin Exp Allergy Date: 2014-01 Impact factor: 5.018
Authors: Carine Blanchard; Emily M Stucke; Karen Burwinkel; Julie M Caldwell; Margaret H Collins; Annette Ahrens; Bridget K Buckmeier; Sean C Jameson; Allison Greenberg; Ajay Kaul; James P Franciosi; Jonathan P Kushner; Lisa J Martin; Philip E Putnam; J Pablo Abonia; Suzanne I Wells; Marc E Rothenberg Journal: J Immunol Date: 2010-03-05 Impact factor: 5.422
Authors: Chris A Liacouras; Glenn T Furuta; Ikuo Hirano; Dan Atkins; Stephen E Attwood; Peter A Bonis; A Wesley Burks; Mirna Chehade; Margaret H Collins; Evan S Dellon; Ranjan Dohil; Gary W Falk; Nirmala Gonsalves; Sandeep K Gupta; David A Katzka; Alfredo J Lucendo; Jonathan E Markowitz; Richard J Noel; Robert D Odze; Philip E Putnam; Joel E Richter; Yvonne Romero; Eduardo Ruchelli; Hugh A Sampson; Alain Schoepfer; Nicholas J Shaheen; Scott H Sicherer; Stuart Spechler; Jonathan M Spergel; Alex Straumann; Barry K Wershil; Marc E Rothenberg; Seema S Aceves Journal: J Allergy Clin Immunol Date: 2011-04-07 Impact factor: 10.793
Authors: W Asher Wolf; Kevin Z Huang; Raquel Durban; Zahra J Iqbal; Benjamin S Robey; Farah J Khalid; Evan S Dellon Journal: Dysphagia Date: 2016-08-09 Impact factor: 3.438
Authors: Katherine G Langley; Jordan Brown; Richard J Gerber; Janelle Fox; Michael J Friez; Michael Lyons; Samantha A Schrier Vergano Journal: Am J Med Genet A Date: 2015-09-04 Impact factor: 2.802
Authors: Mario Noti; Elia D Tait Wojno; Brian S Kim; Mark C Siracusa; Paul R Giacomin; Meera G Nair; Alain J Benitez; Kathryn R Ruymann; Amanda B Muir; David A Hill; Kudakwashe R Chikwava; Amin E Moghaddam; Quentin J Sattentau; Aneesh Alex; Chao Zhou; Jennifer H Yearley; Paul Menard-Katcher; Masato Kubo; Kazushige Obata-Ninomiya; Hajime Karasuyama; Michael R Comeau; Terri Brown-Whitehorn; Rene de Waal Malefyt; Patrick M Sleiman; Hakon Hakonarson; Antonella Cianferoni; Gary W Falk; Mei-Lun Wang; Jonathan M Spergel; David Artis Journal: Nat Med Date: 2013-07-21 Impact factor: 53.440
Authors: Glenn T Furuta; Chris A Liacouras; Margaret H Collins; Sandeep K Gupta; Chris Justinich; Phil E Putnam; Peter Bonis; Eric Hassall; Alex Straumann; Marc E Rothenberg Journal: Gastroenterology Date: 2007-08-08 Impact factor: 22.682
Authors: Patrick M A Sleiman; Mei-Lun Wang; Antonella Cianferoni; Seema Aceves; Nirmala Gonsalves; Kari Nadeau; Albert J Bredenoord; Glenn T Furuta; Jonathan M Spergel; Hakon Hakonarson Journal: Nat Commun Date: 2014-11-19 Impact factor: 14.919
Authors: Silvia Iuliano; Roberta Minelli; Francesca Vincenzi; Federica Gaiani; Claudio Ruberto; Gioacchino Leandro; Barbara Bizzarri; Antonio Nouvenne; Francesco Di Mario; Gian Luigi De'Angelis Journal: Acta Biomed Date: 2018-12-17