| Literature DB >> 28651983 |
Chongning Lv1, Fan Yang1, Rulan Qin2, Zheyuan Qi1, Wanrong Zhou1, Jincai Lu3.
Abstract
Three new compounds (1, 6, 9), with six known compounds (2-5, 7-8) were obtained from water-soluble extract of Cimicifuga dahurica (Turcz.) Maxim. by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. H2O2-induced neurotoxicity on PC12 cells model were conducted to evaluate the neuro-protective capability of these compounds. The piscidic acid derivatives compounds 4-7 showed marked neuro-protective effect at certain concentration.Entities:
Keywords: Cimicifuga dahurica (Turcz.) Maxim.; Cyclolanostane triterpenes; Neuro-protective; Piscidic acid derivatives
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Year: 2017 PMID： 28651983 DOI： 10.1016/j.bmcl.2017.06.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823