Matthew A Tucker1, Reva Crandall2, Nichole Seigler1, Paula Rodriguez-Miguelez1, Kathleen T McKie3, Caralee Forseen4, Jeffrey Thomas1, Ryan A Harris5. 1. Georgia Prevention Institute, Augusta University, Augusta, Georgia, United States. 2. Georgia Prevention Institute, Augusta University, Augusta, Georgia, United States; Pediatric Pulmonology, Augusta University, Augusta, Georgia, United States. 3. Pediatric Pulmonology, Augusta University, Augusta, Georgia, United States. 4. Pulmonary and Critical Care Medicine, Augusta University, Augusta, Georgia, United States. 5. Georgia Prevention Institute, Augusta University, Augusta, Georgia, United States; Sport and Exercise Sciences Research Institute, Ulster University, Jordanstown, Northern Ireland, United Kingdom. Electronic address: ryharris@augusta.edu.
Abstract
BACKGROUND: Responses to a single bout of exercise may provide critical information for maximizing improvements in pulmonary function following exercise training in cystic fibrosis (CF). We sought to determine if acute maximal exercise improves pulmonary function in patients with CF. METHODS: Thirty-three patients with CF completed a comprehensive assessment of pulmonary function to determine forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and lung clearance index (LCI) prior to and immediately following maximal aerobic exercise on a cycle ergometer. RESULTS: Following exercise, FVC (∆0.08±0.14L) and FEV1 (∆0.06±0.15L) increased, while LCI decreased (∆-0.71±0.93) (all p<0.05). Changes in FEV1 (%predicted) were associated with peak work (r=0.40, p=0.02) and peak pulmonary ventilation (r=0.45, p=0.01). CONCLUSIONS: A single bout of maximal exercise acutely improves pulmonary function in patients with CF and improvements may be related to peak work and peak pulmonary ventilation.
BACKGROUND: Responses to a single bout of exercise may provide critical information for maximizing improvements in pulmonary function following exercise training in cystic fibrosis (CF). We sought to determine if acute maximal exercise improves pulmonary function in patients with CF. METHODS: Thirty-three patients with CF completed a comprehensive assessment of pulmonary function to determine forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and lung clearance index (LCI) prior to and immediately following maximal aerobic exercise on a cycle ergometer. RESULTS: Following exercise, FVC (∆0.08±0.14L) and FEV1 (∆0.06±0.15L) increased, while LCI decreased (∆-0.71±0.93) (all p<0.05). Changes in FEV1 (%predicted) were associated with peak work (r=0.40, p=0.02) and peak pulmonary ventilation (r=0.45, p=0.01). CONCLUSIONS: A single bout of maximal exercise acutely improves pulmonary function in patients with CF and improvements may be related to peak work and peak pulmonary ventilation.
Authors: Matthew A Tucker; Nichole Lee; Paula Rodriguez-Miguelez; Jacob Looney; Reva H Crandall; Caralee Forseen; Kathleen T McKie; Ryan A Harris Journal: Eur J Appl Physiol Date: 2018-10-24 Impact factor: 3.078