Dan Rong1, Jie Liu2, Xin Jia1, Daniah Al-Nafisee3, Senhao Jia1, Guoyi Sun1, Yue Li4, Weihang Lu1, Haifeng Li5, Hongpeng Zhang1, Xiaohui Ma1, Jiang Xiong1, Xiaoping Liu1, Raouf A Khalil6, Wei Guo7. 1. Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China. 2. Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China; Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 3. School of Medicine, The Royal College of Surgeons, Dublin, Ireland. 4. Department of Cardiovascular Surgery, Chinese PLA Air Force General Hospital, Beijing, China. 5. Department of Vascular and Endovascular Surgery, Shanxian Dongda Hospital, Heze, Shandong, China. 6. Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 7. Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China. Electronic address: guoweiplagh@sina.com.
Abstract
BACKGROUND AND AIMS: Hyperhomocysteineamia (HHcy) has long been suggested as a risk factor for atherosclerosis. However, the association between HHcy and peripheral arterial disease (PAD) is still controversial. There is a lack of research on this topic in the Chinese population. This study aims to provide further results. METHODS: 240 PAD patients and 240 control subjects were evaluated for both serum total homocysteine levels and ankle brachial indexes (ABIs). Multivariable logistic regression models were used to estimate the association between HHcy and the risk of developing PAD. Interaction and stratified analyses were conducted according to age, sex, smoking status, drinking status, and histories of chronic disease. RESULTS: The multivariate logistic regression analyses revealed that the risk of PAD was significantly associated with serum homocysteine levels. The interaction analysis showed no interactive role in the association between HHcy and PAD, indicating that homocysteine was associated with PAD independently of classical vascular risk factors. CONCLUSIONS: In conclusion, HHcy is an independent risk factor for PAD in the Chinese Han population. A prospective and randomized clinical trial of homocysteine lowering therapy in the Chinese population is needed to assess the causal nature of the relationship.
BACKGROUND AND AIMS: Hyperhomocysteineamia (HHcy) has long been suggested as a risk factor for atherosclerosis. However, the association between HHcy and peripheral arterial disease (PAD) is still controversial. There is a lack of research on this topic in the Chinese population. This study aims to provide further results. METHODS: 240 PAD patients and 240 control subjects were evaluated for both serum total homocysteine levels and ankle brachial indexes (ABIs). Multivariable logistic regression models were used to estimate the association between HHcy and the risk of developing PAD. Interaction and stratified analyses were conducted according to age, sex, smoking status, drinking status, and histories of chronic disease. RESULTS: The multivariate logistic regression analyses revealed that the risk of PAD was significantly associated with serum homocysteine levels. The interaction analysis showed no interactive role in the association between HHcy and PAD, indicating that homocysteine was associated with PAD independently of classical vascular risk factors. CONCLUSIONS: In conclusion, HHcy is an independent risk factor for PAD in the Chinese Han population. A prospective and randomized clinical trial of homocysteine lowering therapy in the Chinese population is needed to assess the causal nature of the relationship.
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