Daniel A Wollin1, Andreas Skolarikos, Glenn M Preminger. 1. aDivision of Urologic Surgery, Duke Comprehensive Kidney Stone Center, Durham, North Carolina, USA bDepartment of Urology, National and Kapodistrian University of Athens, Athens, Greece.
Abstract
PURPOSE OF REVIEW: In this article, we aim to review the data regarding associations between obesity and nephrolithiasis to assist with workup and treatment of these intersecting disorders. As obesity has a multifactorial influence on the risk for urinary stone disease, the complicated mechanisms will be discussed to improve diagnosis and management. RECENT FINDINGS: Obesity and metabolic syndrome interact with nephrolithiasis risk factors to produce a myriad of bodily responses that induce stone formation. For this reason, many societies recommend prompt metabolic workup to evaluate the precise causes of stone formation. Data have shown that dietary and directed medical therapies can produce an excellent therapeutic response in this patient population, although the response may be blunted compared with nonobese patients. SUMMARY: Given the increasing number of obese and overweight patients, the urologist should be familiar with the pathophysiology, workup, and treatment of metabolic stone disease in this population, which are outlined here.
PURPOSE OF REVIEW: In this article, we aim to review the data regarding associations between obesity and nephrolithiasis to assist with workup and treatment of these intersecting disorders. As obesity has a multifactorial influence on the risk for urinary stone disease, the complicated mechanisms will be discussed to improve diagnosis and management. RECENT FINDINGS:Obesity and metabolic syndrome interact with nephrolithiasis risk factors to produce a myriad of bodily responses that induce stone formation. For this reason, many societies recommend prompt metabolic workup to evaluate the precise causes of stone formation. Data have shown that dietary and directed medical therapies can produce an excellent therapeutic response in this patient population, although the response may be blunted compared with nonobese patients. SUMMARY: Given the increasing number of obese and overweight patients, the urologist should be familiar with the pathophysiology, workup, and treatment of metabolic stone disease in this population, which are outlined here.
Authors: Enrique Diaz-Convalia; Miguel Angel Arrabal-Polo; Maria Del Carmen Cano-Garcia; Alejandro Dominguez-Amillo; Nelson Canales-Casco; Miguel Arrabal-Martin Journal: Int Urol Nephrol Date: 2018-01-27 Impact factor: 2.370
Authors: Richard J Johnson; Santos E Perez-Pozo; Julian Lopez Lillo; Felix Grases; Jesse D Schold; Masanari Kuwabara; Yuka Sato; Ana Andres Hernando; Gabriela Garcia; Thomas Jensen; Christopher Rivard; Laura G Sanchez-Lozada; Carlos Roncal; Miguel A Lanaspa Journal: BMC Nephrol Date: 2018-11-08 Impact factor: 2.388