Literature DB >> 28650

Salazopyrin in rheumatoid arthritis.

B McConkey, R S Amos, E P Butler, R A Crockson, A P Crockson, L Walsh.   

Abstract

After a 12-week preliminary period of observation 32 patients with consistently active rheumatoid arthritis (RA) were treated for up to 22 weeks with salazopyrin. Seven patients could not tolerate the drug. The remaining 25 patients had a marked improvement in subjective clinical state and significant falls in serum C-reactive protein and the erythrocyte sedimentation rate 6 weeks after treatment began. The improvement was maintained after 22 weeks. The results strongly suggest that further trials with this drug in RA are needed.

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Year:  1978        PMID: 28650     DOI: 10.1007/BF01968673

Source DB:  PubMed          Journal:  Agents Actions        ISSN: 0065-4299


  13 in total

1.  Treatment of rheumatoid arthritis with salicylazosulfapyridine.

Authors:  N SVARTZ
Journal:  Acta Med Scand Suppl       Date:  1958

2.  Salazopyrin in the Treatment of Rheumatoid Arthritis.

Authors:  R J Sinclair; J J Duthie
Journal:  Ann Rheum Dis       Date:  1949-09       Impact factor: 19.103

3.  The treatment of rheumatic polyarthritis with acid azo compounds.

Authors:  N SVARTZ
Journal:  Rheumatism       Date:  1948-04

4.  Further studies of sulphasalazine metabolism in the treatment of ulcerative colitis.

Authors:  G O Cowan; K M Das; M A Eastwood
Journal:  Br Med J       Date:  1977-10-22

5.  The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants.

Authors:  B McConkey; R A Crockson; A P Crockson
Journal:  Q J Med       Date:  1972-04

6.  The effects of some anti-inflammatory drugs on the acute-phase proteins in rheumatoid arthritis.

Authors:  B McConkey; R A Crockson; A P Crockson; A R Wilkinson
Journal:  Q J Med       Date:  1973-10

7.  Salicylazosulfapyridine (salazopyrin or azopyrin) in rheumatoid arthritis and experimental polyarthritis.

Authors:  W C KUZELL; G M GARDNER
Journal:  Calif Med       Date:  1950-12

8.  Pharmacokinetics and azo-link cleavage of salazopyrine in man.

Authors:  R M Lewkonia; H Schröder; D A Evans
Journal:  Gut       Date:  1973-05       Impact factor: 23.059

9.  Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes.

Authors:  R S Amos; T J Constable; R A Crockson; A P Crockson; B McConkey
Journal:  Br Med J       Date:  1977-01-22

10.  Multiple immune complexes and hypocomplementaemia in dermatitis herpetiformis and coeliac disease.

Authors:  I Mohammed; E J Holborow; L Fry; B R Thompson; A V Hoffbrand; J S Stewart
Journal:  Lancet       Date:  1976-09-04       Impact factor: 79.321

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  26 in total

Review 1.  Disease modifying drugs for rheumatoid arthritis: yesterday's treatment today or today's treatment tomorrow?

Authors:  T Pullar
Journal:  Br J Clin Pharmacol       Date:  1990-10       Impact factor: 4.335

2.  Sulphasalazine in rheumatoid arthritis: combination therapy with D-penicillamine or sodium aurothiomalate.

Authors:  M Farr; G Kitas; P A Bacon
Journal:  Clin Rheumatol       Date:  1988-06       Impact factor: 2.980

3.  Rheumatoid arthritis and the gut.

Authors: 
Journal:  Br Med J       Date:  1979-04-28

4.  Sulphasalazine in rheumatoid arthritis: an old drug revived.

Authors:  V C Neumann; K A Grindulis
Journal:  J R Soc Med       Date:  1984-03       Impact factor: 5.344

Review 5.  Do drugs change the course of rheumatoid arthritis?

Authors:  V Wright; R Amos
Journal:  Br Med J       Date:  1980-04-05

6.  History of the development of sulphasalazine in rheumatology.

Authors:  B McConkey
Journal:  Drugs       Date:  1986       Impact factor: 9.546

Review 7.  Variables affecting efficacy and toxicity of sulphasalazine in rheumatoid arthritis. A review.

Authors:  T Pullar; H A Capell
Journal:  Drugs       Date:  1986       Impact factor: 9.546

8.  Effect of acetylator phenotype on efficacy and toxicity of sulphasalazine in rheumatoid arthritis.

Authors:  T Pullar; J A Hunter; H A Capell
Journal:  Ann Rheum Dis       Date:  1985-12       Impact factor: 19.103

9.  Sulphasalazine in ankylosing spondylitis. A radiological, clinical and laboratory assessment.

Authors:  H G Taylor; E J Beswick; P T Dawes
Journal:  Clin Rheumatol       Date:  1991-03       Impact factor: 2.980

10.  Sulphasalazine and regression of rheumatoid nodules.

Authors:  H J Englert; G R Hughes; M J Walport
Journal:  Ann Rheum Dis       Date:  1987-03       Impact factor: 19.103

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