Literature DB >> 28649844

Chemical Constituents with Proprotein Convertase Subtilisin/Kexin Type 9 mRNA Expression Inhibitory Activity from Dried Immature Morus alba Fruits.

Pisey Pel1, Hee-Sung Chae1, Piseth Nhoek1, Young-Mi Kim1, Young-Won Chin1.   

Abstract

Phytochemical investigation for a chloroform-soluble extract of dried Morus alba fruits, selected by proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression monitoring assay in HepG2 cells, led to the isolation of a new benzofuran, isomoracin D (1), and a naturally occurring compound, N-(N-benzoyl-l-phenylalanyl)-l-phenylalanol (2), along with 13 known compounds (3-15). All of the structures were established by NMR spectroscopic data as well as MS analysis. Of the isolates, moracin C (7) was found to inhibit PCSK9 mRNA expression with an IC50 value of 16.8 μM in the HepG2 cells.

Entities:  

Keywords:  Morus alba fruits; N-(N-phenzoyl-l-phenylalanyl)-l-phenylalanol; PCSK9 mRNA expression; isomoracin D; moracin C

Mesh：

Substances：

Year:  2017        PMID： 28649844     DOI： 10.1021/acs.jafc.7b02088

Source DB:  PubMed          Journal:  J Agric Food Chem        ISSN： 0021-8561            Impact factor:   5.279


  10 in total

1.  Discovery of 2,3'-diindolylmethanes as a novel class of PCSK9 modulators.

Authors:  Gabrielle N Winston-McPherson; Haibo Xie; Ka Yang; Xiaoxun Li; Dongxu Shu; Weiping Tang
Journal:  Bioorg Med Chem Lett       Date:  2019-06-12       Impact factor: 2.823

2.  A Chemical Investigation of the Leaves of Morus alba L.

Authors:  Xiao-Yan Chen; Ting Zhang; Xin Wang; Mark T Hamann; Jie Kang; De-Quan Yu; Ruo-Yun Chen
Journal:  Molecules       Date:  2018-04-26       Impact factor: 4.411

3.  Quantum Mechanical Predictions of the Antioxidant Capability of Moracin C Isomers.

Authors:  Angela Parise; Bruna Clara De Simone; Tiziana Marino; Marirosa Toscano; Nino Russo
Journal:  Front Chem       Date:  2021-04-21       Impact factor: 5.221

Review 4.  A Systematic Review on Attenuation of PCSK9 in Relation to Atherogenesis Biomarkers Associated with Natural Products or Plant Bioactive Compounds in In Vitro Studies: A Critique on the Quality and Imprecision of Studies.

Authors:  Rahayu Zulkapli; Mohd Yusmiaidil Putera Mohd Yusof; Suhaila Abd Muid; Seok Mui Wang; Al'Aina Yuhainis Firus Khan; Hapizah Nawawi
Journal:  Int J Environ Res Public Health       Date:  2022-10-08       Impact factor: 4.614

5.  Mulberry leaf powder regulates antioxidative capacity and lipid metabolism in finishing pigs.

Authors:  Yingying Liu; Yinghui Li; Yi Xiao; Yinglin Peng; Jianhua He; Chen Chen; Dingfu Xiao; Yulong Yin; Fengna Li
Journal:  Anim Nutr       Date:  2020-12-18

6.  Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9.

Authors:  Maria Pia Adorni; Nicola Ferri; Silvia Marchianò; Valentina Trimarco; Francesco Rozza; Raffaele Izzo; Franco Bernini; Francesca Zimetti
Journal:  Ther Clin Risk Manag       Date:  2017-12-11       Impact factor: 2.423

7.  Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network.

Authors:  Hee-Sung Chae; Byoung Hoon You; Dong-Yeop Kim; Hankyu Lee; Hyuk Wan Ko; Hyun-Jeong Ko; Young Hee Choi; Sun Shim Choi; Young-Won Chin
Journal:  Sci Rep       Date:  2018-04-30       Impact factor: 4.379

8.  Effect of Double Bond Position on 2-Phenyl-benzofuran Antioxidants: A Comparative Study of Moracin C and Iso-Moracin C.

Authors:  Xican Li; Hong Xie; Ruicai Zhan; Dongfeng Chen
Journal:  Molecules       Date:  2018-03-24       Impact factor: 4.411

9.  Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia.

Authors:  Chenglin Wu; Cong Xi; Junhua Tong; Jing Zhao; Hualiang Jiang; Jiang Wang; Yiping Wang; Hong Liu
Journal:  Acta Pharm Sin B       Date:  2019-06-25       Impact factor: 11.413

10.  Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells.

Authors:  Jagadeesh Nagarajappa Masagalli; Melanayakanakatte Kuberappa BasavanaGowda; Hee-Sung Chae; Won Jun Choi
Journal:  Molecules       Date:  2021-03-02       Impact factor: 4.411
  10 in total

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