Literature DB >> 28649151

Quasi-simultaneous acquisition of nine secondary ions with seven detectors on NanoSIMS50L: application to biological samples.

Christelle Guillermier1,2, Matthew L Steinhauser1,3, Claude P Lechene1,2.   

Abstract

We employed a method of electrostatic peak switching allowing for the quasi-simultaneous measurement of 16O, 18O, C2H, C2D,12C14N, 13C14N, 12C15N, P, and S with the NanoSIMS 50L instrument to derive ratios for D/H, 13C/12C, 18O/16O, and 15N/14N from biological samples. This approach involves two steps: (i) derivation of the D/H ratio from measurements of C2D and C2H and (ii) switching of the voltage on deflection plates located in front of two detectors. The method is reliable and easy to set up compared with the magnetic peak-switching mode usually used to perform this type of analysis.

Entities:  

Keywords:  C2D/C2H ratio; D/H ratio; MIMS; NanoSIMS50L; multi-isotope mass spectrometry; peak switching

Year:  2014        PMID： 28649151      PMCID： PMC5482274          DOI： 10.1002/sia.5496

Source DB:  PubMed          Journal:  Surf Interface Anal        ISSN： 0142-2421            Impact factor:   1.607


  6 in total

1.  Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy.

Authors:  H Mohri; A S Perelson; K Tung; R M Ribeiro; B Ramratnam; M Markowitz; R Kost; A Hurley; L Weinberger; D Cesar; M K Hellerstein; D D Ho
Journal:  J Exp Med       Date:  2001-11-05       Impact factor: 14.307

2.  High-throughput isotopic analysis of RNA microarrays to quantify microbial resource use.

Authors:  Xavier Mayali; Peter K Weber; Eoin L Brodie; Shalini Mabery; Paul D Hoeprich; Jennifer Pett-Ridge
Journal:  ISME J       Date:  2011-12-08       Impact factor: 10.302

3.  Quantitative imaging of nitrogen fixation by individual bacteria within animal cells.

Authors:  Claude P Lechene; Yvette Luyten; Gregory McMahon; Daniel L Distel
Journal:  Science       Date:  2007-09-14       Impact factor: 47.728

4.  Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.

Authors:  Duan-Sun Zhang; Valeria Piazza; Benjamin J Perrin; Agnieszka K Rzadzinska; J Collin Poczatek; Mei Wang; Haydn M Prosser; James M Ervasti; David P Corey; Claude P Lechene
Journal:  Nature       Date:  2012-01-15       Impact factor: 49.962

5.  Mammalian heart renewal by pre-existing cardiomyocytes.

Authors:  Samuel E Senyo; Matthew L Steinhauser; Christie L Pizzimenti; Vicky K Yang; Lei Cai; Mei Wang; Ting-Di Wu; Jean-Luc Guerquin-Kern; Claude P Lechene; Richard T Lee
Journal:  Nature       Date:  2012-12-05       Impact factor: 49.962

6.  Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism.

Authors:  Matthew L Steinhauser; Andrew P Bailey; Samuel E Senyo; Christelle Guillermier; Todd S Perlstein; Alex P Gould; Richard T Lee; Claude P Lechene
Journal:  Nature       Date:  2012-01-15       Impact factor: 49.962
  6 in total
  6 in total

1.  Biological explorations with nanoscale secondary ion mass spectrometry.

Authors:  Frank Gyngard; Matthew L Steinhauser
Journal:  J Anal At Spectrom       Date:  2019-07-10       Impact factor: 4.023

2.  Quantitative imaging of deuterated metabolic tracers in biological tissues with nanoscale secondary ion mass spectrometry.

Authors:  Christelle Guillermier; J Collin Poczatek; Walter R Taylor; Matthew L Steinhauser
Journal:  Int J Mass Spectrom       Date:  2017-08-24       Impact factor: 1.986

3.  Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity.

Authors:  Christelle Guillermier; Pouneh K Fazeli; Soomin Kim; Mingyue Lun; Jonah P Zuflacht; Jessica Milian; Hang Lee; Hugues Francois-Saint-Cyr; Francois Horreard; David Larson; Evan D Rosen; Richard T Lee; Claude P Lechene; Matthew L Steinhauser
Journal:  JCI Insight       Date:  2017-03-09

4.  Imaging mass spectrometry reveals heterogeneity of proliferation and metabolism in atherosclerosis.

Authors:  Christelle Guillermier; Sean P Doherty; Adam G Whitney; Vladimir R Babaev; MacRae F Linton; Matthew L Steinhauser; Jonathan D Brown
Journal:  JCI Insight       Date:  2019-06-06

5.  Metabolic Analysis at the Nanoscale with Multi-Isotope Imaging Mass Spectrometry (MIMS).

Authors:  Derek P Narendra; Matthew L Steinhauser
Journal:  Curr Protoc Cell Biol       Date:  2020-09

6.  Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover.

Authors:  Derek P Narendra; Christelle Guillermier; Frank Gyngard; Xiaoping Huang; Michael E Ward; Matthew L Steinhauser
Journal:  J Cell Biol       Date:  2020-01-06       Impact factor: 10.539
  6 in total

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