Adrian Andrzej Chrobak1, Katarzyna Siuda-Krzywicka2, Grzegorz Przemysław Siwek3, Anna Tereszko4, Weronika Janeczko5, Anna Starowicz-Filip6, Marcin Siwek7, Dominika Dudek7. 1. Department of Psychiatry, Jagiellonian University, Medical College, Kraków, Poland. Electronic address: adrian.chrobak@student.uj.edu.pl. 2. Department of Psychophysiology, Faculty of Psychology, Jagiellonian University, Kraków, Poland; Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France. 3. Faculty of Medicine, Jagiellonian University, Medical College, Kraków, Poland. 4. Department of Psychiatry, Jagiellonian University, Medical College, Kraków, Poland. 5. Students' Scientific Association of Affective Disorders, Jagiellonian University, Medical College, Kraków, Poland. 6. Medical Psychology Department, Jagiellonian University, Medical College, Kraków, Poland. 7. Department of Affective Disorders, Chair of Psychiatry, Jagiellonian University, Medical College, Kraków, Poland.
Abstract
BACKGROUND: Impairment of implicit motor sequence learning was shown in schizophrenia (SZ) and, most recently, in bipolar disorder (BD), and was connected to cerebellar abnormalities. The goal of this study was to compare implicit motor sequence learning in BD and SZ. METHODS: We examined 33 patients with BD, 33 patients with SZ and 31 healthy controls with a use of ambidextrous Serial Reaction Time Task (SRTT), which allows exploring asymmetries in performance depending on the hand used. RESULTS: BD and SZ patients presented impaired implicit motor sequence learning, although the pattern of their impairments was different. While BD patients showed no signs of implicit motor sequence learning for both hands, the SZ group presented some features of motor learning when performing with the right, but not with the left hand. CONCLUSIONS: To our best knowledge this is the first study comparing implicit motor sequence learning in BD and SZ. We show that both diseases share impairments in this domain, however in the case of SZ this impairment differs dependently on the hand performing SRTT. We propose that implicit motor sequence learning impairments constitute an overlapping symptom in BD and SZ and suggest further neuroimaging studies to verify cerebellar underpinnings as its cause.
BACKGROUND: Impairment of implicit motor sequence learning was shown in schizophrenia (SZ) and, most recently, in bipolar disorder (BD), and was connected to cerebellar abnormalities. The goal of this study was to compare implicit motor sequence learning in BD and SZ. METHODS: We examined 33 patients with BD, 33 patients with SZ and 31 healthy controls with a use of ambidextrous Serial Reaction Time Task (SRTT), which allows exploring asymmetries in performance depending on the hand used. RESULTS: BD and SZ patients presented impaired implicit motor sequence learning, although the pattern of their impairments was different. While BD patients showed no signs of implicit motor sequence learning for both hands, the SZ group presented some features of motor learning when performing with the right, but not with the left hand. CONCLUSIONS: To our best knowledge this is the first study comparing implicit motor sequence learning in BD and SZ. We show that both diseases share impairments in this domain, however in the case of SZ this impairment differs dependently on the hand performing SRTT. We propose that implicit motor sequence learning impairments constitute an overlapping symptom in BD and SZ and suggest further neuroimaging studies to verify cerebellar underpinnings as its cause.
Authors: Katherine S F Damme; Natalie Gallagher; Teresa Vargas; K Juston Osborne; Tina Gupta; Vijay A Mittal Journal: Schizophr Res Date: 2019-04-15 Impact factor: 4.939