Grace Y Lam1, Michelle Doll-Shankaruk2, Jan Dayton3, Karina Rodriguez-Capote4, Trefor N Higgins4, Dylan Thomas4, Kimberley Mulchey5, Maeve P Smith5, Neil E Brown5, Winnie M Leung5, Mathew P Estey6. 1. Division of Internal Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2R3, Canada. 2. Adult Cystic Fibrosis Clinic, Alberta Health Services, Edmonton T6G 1Z1, Canada. 3. DynaLIFE Medical Labs, Edmonton T5J 5E2, Canada. 4. DynaLIFE Medical Labs, Edmonton T5J 5E2, Canada; Department of Laboratory Medicine and Pathology, University of Alberta, T6G 2R3, Canada. 5. Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2R3, Canada. 6. DynaLIFE Medical Labs, Edmonton T5J 5E2, Canada; Department of Laboratory Medicine and Pathology, University of Alberta, T6G 2R3, Canada. Electronic address: mathew.estey@dynalifedx.com.
Abstract
OBJECTIVE: To determine whether serum fructosamine correlates with glycemic control and clinical outcomes in patients being screened for cystic fibrosis-related diabetes (CFRD). METHODS: Fructosamine and percent predicted forced expiratory volume in 1s (FEV1) were measured in patients undergoing a 2h oral glucose tolerance test (OGTT) for CFRD screening. Fractional serum fructosamine (FSF) was calculated as fructosamine/total protein. RESULTS: FSF exhibited a positive correlation with 2h OGTT results (r2=0.3201, p=0.009), and ROC curve analysis suggested that FSF can identify patients with an abnormal OGTT (AUC=0.840, p=0.0002). FSF also exhibited a negative correlation with FEV1 (r2=0.3732, p=0.035). Patients with FSF≥3.70μmol/g had significantly lower FEV1 (median 47%) compared to those with FSF<3.70μmol/g (median 90%; p=0.015). CONCLUSIONS: FSF correlated with both OGTT results and FEV1, and reliably identified patients with abnormal OGTT results. This simple blood test shows potential as an effective tool in CFRD screening.
OBJECTIVE: To determine whether serum fructosamine correlates with glycemic control and clinical outcomes in patients being screened for cystic fibrosis-related diabetes (CFRD). METHODS:Fructosamine and percent predicted forced expiratory volume in 1s (FEV1) were measured in patients undergoing a 2h oral glucose tolerance test (OGTT) for CFRD screening. Fractional serum fructosamine (FSF) was calculated as fructosamine/total protein. RESULTS:FSF exhibited a positive correlation with 2h OGTT results (r2=0.3201, p=0.009), and ROC curve analysis suggested that FSF can identify patients with an abnormal OGTT (AUC=0.840, p=0.0002). FSF also exhibited a negative correlation with FEV1 (r2=0.3732, p=0.035). Patients with FSF≥3.70μmol/g had significantly lower FEV1 (median 47%) compared to those with FSF<3.70μmol/g (median 90%; p=0.015). CONCLUSIONS:FSF correlated with both OGTT results and FEV1, and reliably identified patients with abnormal OGTT results. This simple blood test shows potential as an effective tool in CFRD screening.
Authors: Vera Dóra Izsák; Alexandra Soós; Zsolt Szakács; Péter Hegyi; Márk Félix Juhász; Orsolya Varannai; Ágnes Rita Martonosi; Mária Földi; Alexandra Kozma; Zsolt Vajda; James Am Shaw; Andrea Párniczky Journal: Biomolecules Date: 2021-03-31