Muhammad Hassan Raza1, Sami Siraj2, Abida Arshad3, Usman Waheed4, Fahad Aldakheel5, Shatha Alduraywish6, Muhammad Arshad7. 1. Department of Bioinformatics and Biotechnology, International Islamic University, Sector H-10, Islamabad, 44000, Pakistan. Hassan.bsbt755@iiu.edu.pk. 2. Institute of Basic Medical Sciences, Khyber Medical University (KMU), Peshawar, 25000, Pakistan. 3. Department of Biology, PMAS-Arid Agriculture University, Rawalpindi, 46000, Pakistan. 4. Department of Pathology and Blood Bank, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, 44000, Pakistan. 5. Department of Clinical Laboratory Medicine, College of Applied Medical Sciences, King Saud University, Riyadh, 11564, Saudi Arabia. 6. Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, 11564, Saudi Arabia. 7. Department of Bioinformatics and Biotechnology, International Islamic University, Sector H-10, Islamabad, 44000, Pakistan.
Abstract
PURPOSE: Reactive oxygen species (ROS) are produced in cancer cells as a result of increased metabolic rate, dysfunction of mitochondria, elevated cell signaling, expression of oncogenes and increased peroxisome activities. Certain level of ROS is required by cancer cells, above or below which lead to cytotoxicity in cancer cells. This biochemical aspect can be exploited to develop novel therapeutic agents to preferentially and selectively target cancer cells. METHODS: We searched various electronic databases including PubMed, Web of Science, and Google Scholar for peer-reviewed english-language articles. Selected articles ranging from research papers, clinical studies, and review articles on the ROS production in living systems, its role in cancer development and cancer treatment, and the role of microbiota in ROS-dependent cancer therapy were analyzed. RESULTS: This review highlights oxidative stress in tumors, underlying mechanisms of different relationships of ROS and cancer cells, different ROS-mediated therapeutic strategies and the emerging role of microbiota in cancer therapy. CONCLUSION: Cancer cells exhibit increased ROS stress and disturbed redox homeostasis which lead to ROS adaptations. ROS-dependent anticancer therapies including ROS scavenging anticancer therapy and ROS boosting anticancer therapy have shown promising results in vitro as well as in vivo. In addition, response to cancer therapy is modulated by the human microbiota which plays a critical role in systemic body functions.
PURPOSE:Reactive oxygen species (ROS) are produced in cancer cells as a result of increased metabolic rate, dysfunction of mitochondria, elevated cell signaling, expression of oncogenes and increased peroxisome activities. Certain level of ROS is required by cancer cells, above or below which lead to cytotoxicity in cancer cells. This biochemical aspect can be exploited to develop novel therapeutic agents to preferentially and selectively target cancer cells. METHODS: We searched various electronic databases including PubMed, Web of Science, and Google Scholar for peer-reviewed english-language articles. Selected articles ranging from research papers, clinical studies, and review articles on the ROS production in living systems, its role in cancer development and cancer treatment, and the role of microbiota in ROS-dependent cancer therapy were analyzed. RESULTS: This review highlights oxidative stress in tumors, underlying mechanisms of different relationships of ROS and cancer cells, different ROS-mediated therapeutic strategies and the emerging role of microbiota in cancer therapy. CONCLUSION:Cancer cells exhibit increased ROS stress and disturbed redox homeostasis which lead to ROS adaptations. ROS-dependent anticancer therapies including ROS scavenging anticancer therapy and ROS boosting anticancer therapy have shown promising results in vitro as well as in vivo. In addition, response to cancer therapy is modulated by the human microbiota which plays a critical role in systemic body functions.
Entities:
Keywords:
Antioxidants; Cancer therapy; Microbiota; Pro-oxidants; Reactive oxygen species
Authors: Saeid Ghavami; Ahmad Asoodeh; Thomas Klonisch; Andrew J Halayko; Kamran Kadkhoda; Tadeusz J Kroczak; Spencer B Gibson; Evan P Booy; Hossein Naderi-Manesh; Marek Los Journal: J Cell Mol Med Date: 2008-06 Impact factor: 5.310