Literature DB >> 2864783

Inhibition of [3H] glutamate release from rat hippocampal slices by L-phenylisopropyladenosine.

J Fastbom, B B Fredholm.   

Abstract

Hippocampal slices were labelled with [3H]glutamate. Evoked release, which was calcium-dependent and inhibited by tetrodotoxin, could be reduced concentration-dependently by L-PIA. The effect of L-PIA was blocked by 10 microM 8-phenyltheophylline. The results indicate that there are adenosine receptors modulating the efflux of glutamate in field stimulated hippocampal slices.

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Year:  1985        PMID： 2864783     DOI： 10.1111/j.1748-1716.1985.tb07698.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  18 in total

1.  Transient Adenosine Release Is Modulated by NMDA and GABAB Receptors.

Authors:  Michael D Nguyen; Ying Wang; Mallikarjunarao Ganesana; B Jill Venton
Journal:  ACS Chem Neurosci       Date:  2017-01-30       Impact factor: 4.418

2.  Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia.

Authors:  P Andiné; K A Rudolphi; B B Fredholm; H Hagberg
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

3.  The effect of calcium removal on the suppression by adenosine of epileptiform activity in the hippocampus: demonstration of desensitization.

Authors:  H Hosseinzadeh; T W Stone
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

4.  Anxiolytic activity of adenosine receptor activation in mice.

Authors:  N Jain; N Kemp; O Adeyemo; P Buchanan; T W Stone
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

5.  Release of endogenous adenosine and its metabolites by the activation of NMDA receptors in the rat hippocampus in vivo.

Authors:  Y Chen; D I Graham; T W Stone
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

6.  Endogenous adenosine and adenosine receptors localized to ganglion cells of the retina.

Authors:  K M Braas; M A Zarbin; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

7.  Mediation of the neuroprotective action of R-phenylisopropyl-adenosine through a centrally located adenosine A1 receptor.

Authors:  D G MacGregor; W J Miller; T W Stone
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

8.  Block by N6-L-phenylisopropyl-adenosine of the electrophysiological and morphological correlates of hippocampal ischaemic injury in the gerbil.

Authors:  M R Domenici; A S de Carolis; S Sagratella
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

9.  Inhibition by the adenosine analogue, (R-)-N6-phenylisopropyladenosine, of kainic acid neurotoxicity in rat hippocampus after systemic administration.

Authors:  D G MacGregor; T W Stone
Journal:  Br J Pharmacol       Date:  1993-06       Impact factor: 8.739

10.  Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice.

Authors:  D K Von Lubitz; I A Paul; M Carter; K A Jacobson
Journal:  Eur J Pharmacol       Date:  1993-11-16       Impact factor: 4.432
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