Graciela E Delgado1, Winfried März2, Stefan Lorkowski3, Clemens von Schacky4, Marcus E Kleber5. 1. Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 2. Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany. 3. Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany; Competence Cluster of Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Jena, Germany. 4. Omegametrix, Martinsried, Germany; Department of Preventive Cardiology, Medizinische Klinik und Poliklinik I, Ludwig Maximilians University, Munich, Germany. 5. Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany; Competence Cluster of Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Jena, Germany. Electronic address: marcus.kleber@medma.uni-heidelberg.de.
Abstract
BACKGROUND: Omega-6 polyunsaturated fatty acids (omega-6 PUFA) are recommended in European cardiovascular prevention guidelines. However, individual fatty acids have distinct biological functions, and there have been conflicting reports about the association of omega-6 PUFA with cardiovascular risk. OBJECTIVE: The aim of our study was to investigate the association of individual omega-6 fatty acids with mortality in a cohort of patients referred for coronary angiography. METHODS: Omega-6 PUFA proportions were measured in erythrocytes at baseline in a total of 3259 patients participating in the Ludwigshafen Risk and Cardiovascular Health Study using the HS-Omega-3 Index method. Associations of omega-6 PUFA with mortality were analyzed by Cox regression with adjustment for conventional risk factors. RESULTS: During a median follow-up of 10.0 years, 975 patients (29.9%) died, 614 patients (18.8%) from cardiovascular causes. γ-Linolenic acid was inversely associated with all-cause and cardiovascular mortalities in models adjusted for cardiovascular risk factors with hazard ratios of 0.88 (0.82-0.95) and 0.86 (0.79-0.95) per 1-standard deviation increase, respectively. Adrenic acid and docosapentaenoic acid ω-6 were both directly associated with risk with hazard ratio of 1.10 (1.30-1.18) and 1.12 (1.05-1.19) for all-cause mortality, respectively. No association was found for arachidonic acid. CONCLUSIONS: We observed opposing associations of individual omega-6 PUFA with mortality risk. While LA and γ-linolenic acid were associated with reduced risk, there was a direct association for adrenic acid and docosapentaenoic acid. These differences do not support the use of omega-6 PUFA concentrations as a single combined metric, and the prognostic value of each individual member should be examined separately.
BACKGROUND:Omega-6 polyunsaturated fatty acids (omega-6 PUFA) are recommended in European cardiovascular prevention guidelines. However, individual fatty acids have distinct biological functions, and there have been conflicting reports about the association of omega-6 PUFA with cardiovascular risk. OBJECTIVE: The aim of our study was to investigate the association of individual omega-6 fatty acids with mortality in a cohort of patients referred for coronary angiography. METHODS:Omega-6 PUFA proportions were measured in erythrocytes at baseline in a total of 3259 patients participating in the Ludwigshafen Risk and Cardiovascular Health Study using the HS-Omega-3 Index method. Associations of omega-6 PUFA with mortality were analyzed by Cox regression with adjustment for conventional risk factors. RESULTS: During a median follow-up of 10.0 years, 975 patients (29.9%) died, 614 patients (18.8%) from cardiovascular causes. γ-Linolenic acid was inversely associated with all-cause and cardiovascular mortalities in models adjusted for cardiovascular risk factors with hazard ratios of 0.88 (0.82-0.95) and 0.86 (0.79-0.95) per 1-standard deviation increase, respectively. Adrenic acid and docosapentaenoic acid ω-6 were both directly associated with risk with hazard ratio of 1.10 (1.30-1.18) and 1.12 (1.05-1.19) for all-cause mortality, respectively. No association was found for arachidonic acid. CONCLUSIONS: We observed opposing associations of individual omega-6 PUFA with mortality risk. While LA and γ-linolenic acid were associated with reduced risk, there was a direct association for adrenic acid and docosapentaenoic acid. These differences do not support the use of omega-6 PUFA concentrations as a single combined metric, and the prognostic value of each individual member should be examined separately.
Authors: Sara Bonafini; Angela Tagetti; Rossella Gaudino; Paolo Cavarzere; Martina Montagnana; Elisa Danese; Marco Benati; Diego Alberto Ramaroli; Sara Raimondi; Alice Giontella; Anna Mantovani; Angela Donato; Andrea Dalbeni; Pietro Minuz; Franco Antoniazzi; Claudio Maffeis; Cristiano Fava Journal: Eur J Nutr Date: 2018-03-28 Impact factor: 5.614
Authors: Francisco J Osuna-Prieto; Borja Martinez-Tellez; Jonatan R Ruiz; Sonia Fernández-Veledo; Lourdes Ortiz-Alvarez; Xinyu Di; Lucas Jurado-Fasoli; Huiwen Xu; Victoria Ceperuelo-Mallafré; Catalina Núñez-Roa; Isabelle Kohler; Antonio Segura-Carretero; José V García-Lario; Angel Gil; Concepción M Aguilera; Jose M Llamas-Elvira; Patrick C N Rensen; Joan Vendrell Journal: Cardiovasc Diabetol Date: 2021-07-27 Impact factor: 9.951