Tiago da Silva Alexandre1, Mylène Aubertin-Leheudre2, Lívia Pinheiro Carvalho3, Roberta de Oliveira Máximo3, Ligiana Pires Corona4, Tábatta Renata Pereira de Brito5, Daniella Pires Nunes6, Jair Licio Ferreira Santos7, Yeda Aparecida de Oliveira Duarte8, Maria Lúcia Lebrão9. 1. Department of Epidemiology and Public Health, University College London, London, UK; Gerontology Department, Federal University of São Carlos, São Carlos, Brazil. Electronic address: tsfisioalex@gmail.com. 2. Department of Science of Physical Activity, Montreal, Canada. 3. Physical Therapy Department, Federal University of São Carlos, São Carlos, Brazil. 4. Faculty of Applied Sciences, University of Campinas, Limeira, Brazil. 5. Faculty of Nutrition, Federal University of Alfenas, Alfenas, Brazil. 6. Nursing Department, Federal University of Tocantins, Tocantins, Brazil. 7. Department of Social Medicine, University of São Paulo, Ribeirão Preto, Brazil. 8. Department of Medical-Surgical Nursing, University of São Paulo, São Paulo, Brazil. 9. Department of Epidemiology, University of São Paulo, São Paulo, Brazil.
Abstract
BACKGROUND & AIMS: There is little evidence showing that dynapenic obesity is associated with lipid and glucose metabolism disorders, high blood pressure, chronic disease and metabolic syndrome. Our aim was to analyze whether dynapenic abdominal obesity can be associated with lipid and glucose metabolism disorders, high blood pressure, metabolic syndrome and cardiovascular diseases in older adults living in São Paulo. METHODS: This cross-sectional study included 833 older adults who took part of the third wave of the Health, Well-being and Aging Study in 2010. Based on waist circumference (>88 cm women and >102 cm men) and handgrip strength (<16 kg women and <26 kg men), four groups were identified: non-dynapenic/non-abdominal obese (ND/NAO), abdominal obese alone (AOA), dynapenic alone (DA) and dynapenic/abdominal obese (D/AO). Dependent variables were blood pressure, lipid profile, fasting glucose and glycated-haemoglobin, metabolic syndrome and cardiovascular diseases. Logistic regression was used to analyze the associations between dynapenia and abdominal obesity status and lipid and glucose metabolic profiles, blood pressure, cardiovascular diseases and metabolic syndrome. RESULTS: The fully adjusted models showed that D/AO individuals had higher prevalence of low HDL plasma concentrations (OR = 2.51, 95%CI: 1.40-4.48), hypertriglyceridemia (OR = 2.53, 95%CI: 1.43-4.47), hyperglycemia (OR = 2.05, 95%CI: 1.14-3.69), high glycated-haemoglobin concentrations (OR = 1.84, 95%CI: 1.03-3.30) and metabolic syndrome (OR = 12.39, 95%CI: 7.38-20.79) than ND/NAO. Dynapenic and D/AO individuals had higher prevalence of heart disease (OR = 2.05, 95%CI: 1.17-3.59 and OR = 1.92, 95%CI: 1.06-3.48, respectively) than ND/NAO. CONCLUSION: D/AO was associated with high prevalence of lipid and glucose metabolism disorders and metabolic syndrome while dynapenia and D/AO were associated with high prevalence of heart disease.
BACKGROUND & AIMS: There is little evidence showing that dynapenic obesity is associated with lipid and glucose metabolism disorders, high blood pressure, chronic disease and metabolic syndrome. Our aim was to analyze whether dynapenic abdominal obesity can be associated with lipid and glucose metabolism disorders, high blood pressure, metabolic syndrome and cardiovascular diseases in older adults living in São Paulo. METHODS: This cross-sectional study included 833 older adults who took part of the third wave of the Health, Well-being and Aging Study in 2010. Based on waist circumference (>88 cm women and >102 cm men) and handgrip strength (<16 kg women and <26 kg men), four groups were identified: non-dynapenic/non-abdominal obese (ND/NAO), abdominal obese alone (AOA), dynapenic alone (DA) and dynapenic/abdominal obese (D/AO). Dependent variables were blood pressure, lipid profile, fasting glucose and glycated-haemoglobin, metabolic syndrome and cardiovascular diseases. Logistic regression was used to analyze the associations between dynapenia and abdominal obesity status and lipid and glucose metabolic profiles, blood pressure, cardiovascular diseases and metabolic syndrome. RESULTS: The fully adjusted models showed that D/AO individuals had higher prevalence of low HDL plasma concentrations (OR = 2.51, 95%CI: 1.40-4.48), hypertriglyceridemia (OR = 2.53, 95%CI: 1.43-4.47), hyperglycemia (OR = 2.05, 95%CI: 1.14-3.69), high glycated-haemoglobin concentrations (OR = 1.84, 95%CI: 1.03-3.30) and metabolic syndrome (OR = 12.39, 95%CI: 7.38-20.79) than ND/NAO. Dynapenic and D/AO individuals had higher prevalence of heart disease (OR = 2.05, 95%CI: 1.17-3.59 and OR = 1.92, 95%CI: 1.06-3.48, respectively) than ND/NAO. CONCLUSION: D/AO was associated with high prevalence of lipid and glucose metabolism disorders and metabolic syndrome while dynapenia and D/AO were associated with high prevalence of heart disease.
Authors: Shuang Zhang; Yu Wang; Fang Lu; Shadi A D Mohammed; Hanxing Liu; Song Ding; Shu-Min Liu Journal: Front Pharmacol Date: 2022-04-05 Impact factor: 5.988
Authors: Laura Pérez-Campos Mayoral; Carlos Alberto Matias-Cervantes; Eduardo Pérez-Campos; Carlos Romero Díaz; Luis Ángel Laguna Barrios; María Del Socorro Pina Canseco; Margarito Martínez Cruz; Eduardo Pérez-Campos Mayoral; Carlos Josué Solórzano Mata; Francisco Javier Rodal Canales; Héctor Martínez Ruíz; María Teresa Hernández-Huerta Journal: Int J Mol Sci Date: 2022-07-27 Impact factor: 6.208