| Literature DB >> 28645793 |
S A Machekposhti1, M Soltani2, P Najafizadeh3, S A Ebrahimi3, P Chen4.
Abstract
Recently-introduced biocompatible polymeric microneedles offer an efficient method for drug delivery. Tranexamic acid is a novel drug for treating melasma that is administered both locally and orally and inhibits excessive melanin via melanocyte. The tranexamic acid biocompatible polymer microneedle used in this study was fabricated from PVP and methacrylic acid, using the lithography method. The required mechanical strength to pierce skin was attained by optimizing the ratio of PVP to methacrylic acid. Acute dermal toxicity was done, and drug diffusion in skin layers was simulated by calculating the diffusion coefficient of tranexamic acid in interstitial fluid (plasma). The biocompatible polymer microneedle was fabricated at 60°C. Needles could sustain 0.6N that is enough to pierce stratum corneum. 34% of the released drug was locally effective and the rest permeated through the skin. The pyramidal polymer microneedle in this study was fully released in skin in approx. 7h. This polymer microneedle has no dermal toxicity.Entities:
Keywords: Diffusion coefficient; Drug delivery; Melasma; Polymer microneedle; Polyvinylpyrrolidone; Tranexamic acid
Mesh：
Substances：
Year: 2017 PMID： 28645793 DOI： 10.1016/j.jconrel.2017.06.016
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776