| Literature DB >> 28645529 |
Morgane Berthet1, Yves Gauthier2, Céline Lacroix3, Bernard Verrier3, Claire Monge3.
Abstract
Reconstructing functional skin after a wound remains a challenge due to the complexity of healing. In this regard, biocompatible nanoparticles (NPs) carrying and releasing bioactive drugs in a controlled and sustained manner may significantly improve the efficacy of wound therapies compared with current treatments. Topical administration of drug-loaded NPs allows optimal delivery to the dermis and improves product efficacy. Furthermore, associating NPs with scaffolds represents a new concept of 'dressing'. Experimental in vivo, ex vivo, and in vitro models have been developed in preclinical assays to evaluate the beneficial effects of nanoparticulate dressings. Drug-loaded NPs are promising tools for innovative wound healing treatment, especially with regard to their multifunctional properties.Keywords: biodegradable dressing; drug-delivery system; nanoparticles; skin regeneration; wound healing
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Year: 2017 PMID： 28645529 DOI： 10.1016/j.tibtech.2017.05.005
Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536