Anne B Chang1, John J Oppenheimer2, Miles Weinberger3, Cameron C Grant4, Bruce K Rubin5, Richard S Irwin6. 1. Division of Child Health, Menzies School of Health Research, Lady Cilento Children's Hospital, Qld Uni of Technology Queensland, Australia; Respiratory and Sleep Department, Lady Cilento Children's Hospital, Qld Uni of Technology Queensland, Australia. Electronic address: annechang@ausdoctors.net. 2. Division of Allergy and Immunology, Department of Medicine, New Jersey Medical School, Pulmonary and Allergy Associates, Morristown, NJ. 3. Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, CA. 4. Department of Paediatrics: Child and Youth Health, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand. 5. Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA. 6. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, UMass Memorial Medical Center, Worcester, MA.
Abstract
BACKGROUND: There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? METHODS: We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients' values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. RESULTS: Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. CONCLUSIONS: There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.
BACKGROUND: There is no published systematic review on the etiologies of chronic cough or the relationship between OSA and chronic cough in children aged ≤ 14 years. We thus undertook a systematic review based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format. The KQs follow: Among children with chronic (> 4 weeks) cough (KQ 1) are the common etiologies different from those in adults? (KQ 2) Are the common etiologies age or setting dependent, or both? (KQ 3) Is OSA a cause of chronic cough in children? METHODS: We used the CHEST Expert Cough Panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework. Data from the systematic reviews in conjunction with patients' values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus. RESULTS: Combining KQs 1 and 2, we found moderate-level evidence from 10 prospective studies that the etiologies of cough in children are different from those in adults and are setting dependent. Data from three studies found that common etiologies of cough in young children were different from those in older children. However, data relating sleep abnormalities to chronic cough in children were found only in case studies. CONCLUSIONS: There is moderate-quality evidence that common etiologies of chronic cough in children are different from those in adults and are dependent on age and setting. As there are few data relating OSA and chronic cough in children, the panel suggested that these children should be managed in accordance with pediatric sleep guidelines.
Authors: Julie M Marchant; I Brent Masters; Simone M Taylor; Nancy C Cox; Greg J Seymour; Anne B Chang Journal: Chest Date: 2006-05 Impact factor: 9.410
Authors: Anne B Chang; Peter G Gibson; Carol Willis; Helen L Petsky; John G Widdicombe; I Brent Masters; Colin F Robertson Journal: Chest Date: 2011-03-10 Impact factor: 9.410
Authors: Peter A Newcombe; Jeanie K Sheffield; Elizabeth F Juniper; Julie M Marchant; Ria A Halsted; I Brent Masters; Anne B Chang Journal: Chest Date: 2008-02 Impact factor: 9.410
Authors: Anne B Chang; John J Oppenheimer; Peter J Kahrilas; Ahmad Kantar; Bruce K Rubin; Miles Weinberger; Richard S Irwin Journal: Chest Date: 2019-04-16 Impact factor: 9.410
Authors: Kian Fan Chung; Lorcan McGarvey; Woo-Jung Song; Anne B Chang; Kefang Lai; Brendan J Canning; Surinder S Birring; Jaclyn A Smith; Stuart B Mazzone Journal: Nat Rev Dis Primers Date: 2022-06-30 Impact factor: 65.038
Authors: Corey N Martin; Zhour Barnawi; Elizabeth Chorvinsky; Dhruv Pillai; Meagan Gatti; Maura E Collins; Gina M Krakovsky; Nancy M Bauman; Sona Sehgal; Dinesh K Pillai Journal: Pediatr Pulmonol Date: 2021-05-13
Authors: Lorcan McGarvey; Bruce K Rubin; Satoru Ebihara; Karen Hegland; Alycia Rivet; Richard S Irwin; Donald C Bolser; Anne B Chang; Peter G Gibson; Stuart B Mazzone Journal: Chest Date: 2021-04-24 Impact factor: 10.262