Background: Up to half of patients with Chagas' disease under benznidazole treatment present adverse drug reactions (ADRs) and up to one-third do not complete standard treatment. Objectives: To verify the incidence and possible factors associated with the suspension of benznidazole treatment in a large cohort of patients. Methods: We included 2075 patients treated with benznidazole during the projects managed by the medical humanitarian organization Doctors Without Borders (Médecins Sans Frontières) in Bolivia from 2009 to 2013. Benznidazole treatment was provided two or three times per day for ∼60 days at 5-7.5 mg/kg/day. A multiple logistic regression model was developed to evaluate the factors associated with permanent suspension of benznidazole treatment. Results: Permanent benznidazole treatment suspension occurred in 211 patients (10.2%) and the average time until permanent treatment suspension was 23 days. Multifactorial analysis revealed that female sex (adjusted OR = 1.70), moderate ADRs (adjusted OR = 10.57), mild ADRs (adjusted OR = 1.69) and skin disorders (adjusted OR = 4.18) were significantly associated with the permanent suspension of benznidazole treatment. Women with mild or moderate skin ADRs presented a probability of treatment interruption of 18.6% and 59.0%, respectively. Conclusions: Benznidazole treatment was safe and a large proportion of patients were able to complete a full course of benznidazole treatment under close treatment surveillance. Female sex, skin disorders and mild and moderate ADRs were independently associated with the permanent suspension of benznidazole treatment. In particular, women with moderate skin ADRs had the highest risk of benznidazole treatment interruption.
Background: Up to half of patients with Chagas' disease under benznidazole treatment present adverse drug reactions (ADRs) and up to one-third do not complete standard treatment. Objectives: To verify the incidence and possible factors associated with the suspension of benznidazole treatment in a large cohort of patients. Methods: We included 2075 patients treated with benznidazole during the projects managed by the medical humanitarian organization Doctors Without Borders (Médecins Sans Frontières) in Bolivia from 2009 to 2013. Benznidazole treatment was provided two or three times per day for ∼60 days at 5-7.5 mg/kg/day. A multiple logistic regression model was developed to evaluate the factors associated with permanent suspension of benznidazole treatment. Results: Permanent benznidazole treatment suspension occurred in 211 patients (10.2%) and the average time until permanent treatment suspension was 23 days. Multifactorial analysis revealed that female sex (adjusted OR = 1.70), moderate ADRs (adjusted OR = 10.57), mild ADRs (adjusted OR = 1.69) and skin disorders (adjusted OR = 4.18) were significantly associated with the permanent suspension of benznidazole treatment. Women with mild or moderate skin ADRs presented a probability of treatment interruption of 18.6% and 59.0%, respectively. Conclusions: Benznidazole treatment was safe and a large proportion of patients were able to complete a full course of benznidazole treatment under close treatment surveillance. Female sex, skin disorders and mild and moderate ADRs were independently associated with the permanent suspension of benznidazole treatment. In particular, women with moderate skin ADRs had the highest risk of benznidazole treatment interruption.
Authors: Jessica Vanina Ortiz; Bruna Valessa Moutinho Pereira; Katia do Nascimento Couceiro; Monica Regina Hosannah da Silva E Silva; Susan Smith Doria; Paula Rita Leite da Silva; Edson da Fonseca de Lira; Maria das Graças Vale Barbosa Guerra; Jorge Augusto de Oliveira Guerra; João Marcos Bemfica Barbosa Ferreira Journal: Arq Bras Cardiol Date: 2019-01-07 Impact factor: 2.000
Authors: Filip Zmuda; Lalitha Sastry; Sharon M Shepherd; Deuan Jones; Alison Scott; Peter D Craggs; Alvaro Cortes; David W Gray; Leah S Torrie; Manu De Rycker Journal: Antimicrob Agents Chemother Date: 2019-08-23 Impact factor: 5.938
Authors: Luis Eduardo Echeverría; Rachel Marcus; Gabriel Novick; Sergio Sosa-Estani; Kate Ralston; Ezequiel Jose Zaidel; Colin Forsyth; Antonio Luiz P RIbeiro; Iván Mendoza; Mariano Luis Falconi; Jorge Mitelman; Carlos A Morillo; Ana Cristina Pereiro; María Jesús Pinazo; Roberto Salvatella; Felipe Martinez; Pablo Perel; Álvaro Sosa Liprandi; Daniel José Piñeiro; Gustavo Restrepo Molina Journal: Glob Heart Date: 2020-03-30
Authors: I Jimeno; N Mendoza; F Zapana; L de la Torre; F Torrico; D Lozano; C Billot; M J Pinazo Journal: PLoS One Date: 2021-08-12 Impact factor: 3.240