CONTEXT: - Cervical adenocarcinomas span a diverse group of tumors with several distinct histologic tumor types, which include endocervical, endometrioid, intestinal, villoglandular, gastric, signet ring, serous, clear cell, and mesonephric. Diagnosis of cervical adenocarcinoma, especially early diagnosis, poses a significant challenge. OBJECTIVE: - To review the pathogenesis, diagnostic criteria, immunohistochemical markers, and differential diagnosis of various subtypes of human papillomavirus (HPV)-positive and HPV-negative cervical adenocarcinomas. The paper presents a concise summary of the issues that may be particularly difficult in histopathologic diagnosis, such as differentiating neoplastic lesions from benign mimics, determining the tumor type, differentiating early invasive lesions from adenocarcinoma in situ, measuring the depth of invasion, and, finally, differentiating primary cervical adenocarcinoma from uterine endometrioid adenocarcinoma and tumors metastatic from other primary sites. DATA SOURCES: - The study employed a PubMed search of recently published reports. CONCLUSIONS: - Early detection of HPV-positive tumor types may be aided with the expansion of HPV testing; however, early diagnosis of HPV-negative cervical adenocarcinomas will continue to pose a challenge and may require the development of additional molecular testing techniques.
CONTEXT: - Cervical adenocarcinomas span a diverse group of tumors with several distinct histologic tumor types, which include endocervical, endometrioid, intestinal, villoglandular, gastric, signet ring, serous, clear cell, and mesonephric. Diagnosis of cervical adenocarcinoma, especially early diagnosis, poses a significant challenge. OBJECTIVE: - To review the pathogenesis, diagnostic criteria, immunohistochemical markers, and differential diagnosis of various subtypes of human papillomavirus (HPV)-positive and HPV-negative cervical adenocarcinomas. The paper presents a concise summary of the issues that may be particularly difficult in histopathologic diagnosis, such as differentiating neoplastic lesions from benign mimics, determining the tumor type, differentiating early invasive lesions from adenocarcinoma in situ, measuring the depth of invasion, and, finally, differentiating primary cervical adenocarcinoma from uterine endometrioid adenocarcinoma and tumors metastatic from other primary sites. DATA SOURCES: - The study employed a PubMed search of recently published reports. CONCLUSIONS: - Early detection of HPV-positive tumor types may be aided with the expansion of HPV testing; however, early diagnosis of HPV-negative cervical adenocarcinomas will continue to pose a challenge and may require the development of additional molecular testing techniques.
Authors: Isabel Alvarado-Cabrero; W Glenn McCluggage; Rafael Estevez-Castro; Delia Pérez-Montiel; Simona Stolnicu; Raji Ganesan; Josefa Vella; Rosario Castro; Javier Canedo-Matute; Jessica Gomez-Cifuentes; Vilma M Rivas-Lemus; Kay J Park; Robert A Soslow; Esther Oliva; Raquel Valencia-Cedillo Journal: Am J Surg Pathol Date: 2019-06 Impact factor: 6.394
Authors: Anna Rosa Garbuglia; Daniele Lapa; Catia Sias; Maria Rosaria Capobianchi; Paola Del Porto Journal: Front Immunol Date: 2020-02-18 Impact factor: 7.561
Authors: Ran C Zhang; Nujsaubnusi C Vue; Lisa U Obasi; Rachel I Vogel; Amar T Subramanian; Mahmoud A Khalifa; Buvana R Reddy; Britt K Erickson Journal: J Low Genit Tract Dis Date: 2021-10-01 Impact factor: 3.842