Pasquale Calabrese1, Gisela Kobelt2, Jenny Berg3, Daniela Capsa3, Jennifer Eriksson3. 1. Division of Molecular and Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland. 2. European Health Economics, Mulhouse, France. 3. Mapi Group, Stockholm, Sweden.
Abstract
INTRODUCTION: To estimate the value of interventions in multiple sclerosis (MS) - where lifetime costs and outcomes cannot be observed - outcome data have to be combined with costs. This requires that cost data be regularly updated. OBJECTIVES AND METHODS: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS. Descriptive analyses are presented by level of severity, from the societal perspective, in CHF 2015. RESULTS: A total of 721 patients (mean age 48 years) participated in Switzerland; 90% were below retirement age, and of these, 65% were employed. Employment was related to disease severity, and MS affected productivity at work for 69% of patients. Overall, 93% and 64% of patients experienced fatigue and cognition as a problem, respectively. The mean utility and annual costs were 0.799 and 29,600CHF at Expanded Disability Status Scale (EDSS) 0-3, 0.614 and 66,800CHF at EDSS 4-6.5 and 0.348 and 110,800CHF at EDSS 7-9, respectively. The mean cost of a relapse was estimated at 7600CHF. CONCLUSION: This study provides current data on MS in Switzerland that are important for development of health policies and to estimate the value of current and future treatments.
INTRODUCTION: To estimate the value of interventions in multiple sclerosis (MS) - where lifetime costs and outcomes cannot be observed - outcome data have to be combined with costs. This requires that cost data be regularly updated. OBJECTIVES AND METHODS: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS. Descriptive analyses are presented by level of severity, from the societal perspective, in CHF 2015. RESULTS: A total of 721 patients (mean age 48 years) participated in Switzerland; 90% were below retirement age, and of these, 65% were employed. Employment was related to disease severity, and MS affected productivity at work for 69% of patients. Overall, 93% and 64% of patients experienced fatigue and cognition as a problem, respectively. The mean utility and annual costs were 0.799 and 29,600CHF at Expanded Disability Status Scale (EDSS) 0-3, 0.614 and 66,800CHF at EDSS 4-6.5 and 0.348 and 110,800CHF at EDSS 7-9, respectively. The mean cost of a relapse was estimated at 7600CHF. CONCLUSION: This study provides current data on MS in Switzerland that are important for development of health policies and to estimate the value of current and future treatments.
Authors: Marco Kaufmann; Jens Kuhle; Milo A Puhan; Christian P Kamm; Andrew Chan; Anke Salmen; Jürg Kesselring; Pasquale Calabrese; Claudio Gobbi; Caroline Pot; Nina Steinemann; Stephanie Rodgers; Viktor von Wyl Journal: Mult Scler J Exp Transl Clin Date: 2018-12-06
Authors: Laura Barin; Christian P Kamm; Anke Salmen; Holger Dressel; Pasquale Calabrese; Caroline Pot; Sven Schippling; Claudio Gobbi; Stefanie Müller; Andrew Chan; Stephanie Rodgers; Marco Kaufmann; Vladeta Ajdacic-Gross; Nina Steinemann; Jürg Kesselring; Milo A Puhan; Viktor von Wyl Journal: Mult Scler Date: 2019-01-18 Impact factor: 6.312
Authors: Anja I Lehmann; Stephanie Rodgers; Christian P Kamm; Mathias Mettler; Nina Steinemann; Vladeta Ajdacic-Gross; Marco Kaufmann; Jürg Kesselring; Pasquale Calabrese; Anke Salmen; Claudio Gobbi; Chiara Zecca; Georg F Bauer; Viktor von Wyl Journal: J Neurol Date: 2020-06-11 Impact factor: 4.849
Authors: Marco Kaufmann; Milo Alan Puhan; Anke Salmen; Christian P Kamm; Zina-Mary Manjaly; Pasquale Calabrese; Sven Schippling; Stefanie Müller; Jens Kuhle; Caroline Pot; Claudio Gobbi; Nina Steinemann; Viktor von Wyl Journal: Front Neurol Date: 2020-03-06 Impact factor: 4.003