| Literature DB >> 2864301 |
K Sekiya, A Funakoshi, H Shinozaki, H Nawata, K Kato, H Ibayashi.
Abstract
To determine the effects of methionine-enkephalin on secretion of pancreatic hormones, five healthy male adults were intramuscularly given 0.5 mg of FK 33-824, a methionine-enkephalin analog and blood levels of pancreatic hormones were measured at different time intervals. FK 33-824 significantly lowered basal levels of plasma insulin (IRI) and pancreatic polypeptide and decreased IRI secretion in 75 g-OGTT. It also delayed the elevation of blood sugar level in 75 g-OGTT. No change occurred in the basal levels of plasma glucagon, somatostatin and blood sugar. These results imply that methionine-enkephalin in the pancreas and alimentary tract may act as an inhibitor on the secretion of insulin and pancreatic polypeptide and hence relates to the absorption of sugar.Entities:
Mesh：
Substances：
Year: 1985 PMID： 2864301 DOI： 10.1007/bf02774712
Source DB: PubMed Journal: Gastroenterol Jpn ISSN： 0435-1339