Literature DB >> 28642119

Targeting inflammation for the treatment of alcoholic liver disease.

Ming-Jiang Xu1, Zhou Zhou1, Richard Parker2, Bin Gao3.   

Abstract

Alcoholic liver disease (ALD) is a leading cause of chronic liver disease with a wide spectrum of manifestations including simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Liver injury in ALD is caused by chronic inflammation, which has been actively investigated as a therapeutic target for the treatment of ALD for over the last four decades. In this review, we summarize a wide variety of inflammatory mediators that have been shown to contribute to the pathogenesis of ALD, and discuss the therapeutic potential of these mediators for the treatment of ALD. Published by Elsevier Inc.

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Year:  2017        PMID： 28642119      PMCID： PMC5677537          DOI： 10.1016/j.pharmthera.2017.06.007

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  199 in total

1.  Chronic ethanol consumption inhibits hepatic natural killer cell activity and accelerates murine cytomegalovirus-induced hepatitis.

Authors:  Hong-na Pan; Rui Sun; Barbara Jaruga; Feng Hong; Won-Ho Kim; Bin Gao
Journal:  Alcohol Clin Exp Res       Date:  2006-09       Impact factor: 3.455

2.  The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry.

Authors:  Alina Simerzin; Elina Zorde-Khvalevsky; Mila Rivkin; Revital Adar; Jessica Zucman-Rossi; Gabrielle Couchy; Tania Roskams; Olivier Govaere; Moshe Oren; Hilla Giladi; Eithan Galun
Journal:  Hepatology       Date:  2016-07-25       Impact factor: 17.425

3.  The Role of miR-212 and iNOS in Alcohol-Induced Intestinal Barrier Dysfunction and Steatohepatitis.

Authors:  Yueming Tang; Lijuan Zhang; Christopher B Forsyth; Maliha Shaikh; Shiwen Song; Ali Keshavarzian
Journal:  Alcohol Clin Exp Res       Date:  2015-07-24       Impact factor: 3.455

4.  Effects of Kupffer cell inactivation on graft survival and liver regeneration after partial liver transplantation in rats.

Authors:  Hang-Yu Luo; Shan-Fang Ma; Ji-Fu Qu; De-Hu Tian
Journal:  Hepatobiliary Pancreat Dis Int       Date:  2015-02

5.  Granulocyte colony-stimulating factor in severe alcoholic hepatitis: a randomized pilot study.

Authors:  Virendra Singh; Arun K Sharma; R Lakshmi Narasimhan; Ashish Bhalla; Navneet Sharma; Ratiram Sharma
Journal:  Am J Gastroenterol       Date:  2014-06-17       Impact factor: 10.864

6.  Human hepatocytes metabolizing ethanol generate a non-polar chemotactic factor for human neutrophils.

Authors:  F J Roll; D M Bissell; H D Perez
Journal:  Biochem Biophys Res Commun       Date:  1986-06-13       Impact factor: 3.575

7.  Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis.

Authors:  Won-Il Jeong; Ogyi Park; Bin Gao
Journal:  Gastroenterology       Date:  2007-09-29       Impact factor: 22.682

Review 8.  Neutrophilic infiltration in alcoholic hepatitis.

Authors:  Abraham P Bautista
Journal:  Alcohol       Date:  2002-05       Impact factor: 2.405

9.  Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

Authors:  Karsten Buschard; Axel Kornerup Hansen; Karen Jensen; Dicky J Lindenbergh-Kortleve; Lilian F de Ruiter; Thomas C Krohn; Majbritt R Hufeldt; Finn K Vogensen; Bent Aasted; Thomas Osterbye; Bart O Roep; Colin de Haar; Edward E Nieuwenhuis
Journal:  PLoS One       Date:  2011-04-01       Impact factor: 3.240

10.  The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease.

Authors:  Stéphanie Patouraux; Stéphanie Bonnafous; Cosmin S Voican; Rodolphe Anty; Marie-Christine Saint-Paul; Maria-Alessandra Rosenthal-Allieri; Hélène Agostini; Micheline Njike; Nadége Barri-Ova; Sylvie Naveau; Yannick Le Marchand-Brustel; Pascal Veillon; Paul Calès; Gabriel Perlemuter; Albert Tran; Philippe Gual
Journal:  PLoS One       Date:  2012-04-18       Impact factor: 3.240
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  20 in total

Review 1.  Inflammatory pathways in alcoholic steatohepatitis.

Authors:  Bin Gao; Maleeha F Ahmad; Laura E Nagy; Hidekazu Tsukamoto
Journal:  J Hepatol       Date:  2019-02       Impact factor: 25.083

Review 2.  A Unifying Hypothesis Linking Hepatic Adaptations for Ethanol Metabolism to the Proinflammatory and Profibrotic Events of Alcoholic Liver Disease.

Authors:  Zhi Zhong; John J Lemasters
Journal:  Alcohol Clin Exp Res       Date:  2018-09-17       Impact factor: 3.455

Review 3.  Endocrine Adiponectin-FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury.

Authors:  Min You; Zhou Zhou; Michael Daniels; Alvin Jogasuria
Journal:  Gene Expr       Date:  2017-11-02

Review 4.  Alcoholic liver disease.

Authors:  Helmut K Seitz; Ramon Bataller; Helena Cortez-Pinto; Bin Gao; Antoni Gual; Carolin Lackner; Philippe Mathurin; Sebastian Mueller; Gyongyi Szabo; Hidekazu Tsukamoto
Journal:  Nat Rev Dis Primers       Date:  2018-08-16       Impact factor: 52.329

5.  Anti-Oxidant and Anti-Inflammatory Effects of Lipopolysaccharide from Rhodobacter sphaeroides against Ethanol-Induced Liver and Kidney Toxicity in Experimental Rats.

Authors:  Eman T Mehanna; Al-Shimaa A Ali; Fatma El-Shaarawy; Noha M Mesbah; Dina M Abo-Elmatty; Nora M Aborehab
Journal:  Molecules       Date:  2021-12-08       Impact factor: 4.411

Review 6.  Regulation and functional roles of chemokines in liver diseases.

Authors:  Sheng Cao; Mengfei Liu; Tejasav S Sehrawat; Vijay H Shah
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2021-05-11       Impact factor: 73.082

7.  Effect of Lycosome-Formulated Phosphatidylcholine on Parameters of Biological Oxidation after Single Intake of Moderate Amount of Alcohol.

Authors:  Ivan M Petyaev; Marina P Chernyshova; Dmitry V Pristensky; Natalia E Chalyk; Victor A Klochkov; Nigel H Kyle; Yuriy K Bashmakov
Journal:  Adv Prev Med       Date:  2018-07-30

8.  Plasma levels of soluble ST2, but not IL-33, correlate with the severity of alcoholic liver disease.

Authors:  Zijian Sun; Binxia Chang; Ang Huang; Shuli Hao; Miaomiao Gao; Ying Sun; Ming Shi; Lei Jin; Wei Zhang; Jun Zhao; Guangju Teng; Lin Han; Hui Tian; Qingsheng Liang; Ji-Yuan Zhang; Zhengsheng Zou
Journal:  J Cell Mol Med       Date:  2018-11-27       Impact factor: 5.310

9.  Hepatoprotective Effects of Morchella esculenta against Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling.

Authors:  Bo Meng; Yuanzhu Zhang; Zhuqian Wang; Qinran Ding; Jia Song; Di Wang
Journal:  Oxid Med Cell Longev       Date:  2019-07-17       Impact factor: 6.543

10.  NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease.

Authors:  Yaru Li; Mingming Chen; Yu Zhou; Chuanfeng Tang; Wen Zhang; Ying Zhong; Yadong Chen; Hong Zhou; Liang Sheng
Journal:  Theranostics       Date:  2020-02-18       Impact factor: 11.556
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