Elin Chorell1, Ulrika Andersson Hall2, Carolina Gustavsson2, Kerstin Berntorp3, Jatta Puhkala4, Riitta Luoto4, Tommy Olsson5, Agneta Holmäng2. 1. Department of Public Health and Clinical Medicine, Umeå University. Electronic address: elin.chorell@umu.se. 2. Institute of Neuroscience and Physiology, University of Gothenburg. 3. Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Endocrinology, Skåne University Hospital, Malmö, Sweden. 4. UKK Institute for Health Promotion Research, Tampere, Finland,; National Institute for Health and Welfare, Helsinki, Finland. 5. Department of Public Health and Clinical Medicine, Umeå University.
Abstract
CONTEXT: Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. OBJECTIVE: To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. DESIGN: The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32±0.6) and postpartum (10.5±0.4months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period. RESULTS: Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women. CONCLUSIONS: Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy.
CONTEXT: Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. OBJECTIVE: To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. DESIGN: The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32±0.6) and postpartum (10.5±0.4months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period. RESULTS:Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women. CONCLUSIONS: Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy.
Authors: Tianyi Huang; Oana A Zeleznik; Andrea L Roberts; Raji Balasubramanian; Clary B Clish; A Heather Eliassen; Kathryn M Rexrode; Shelley S Tworoger; Susan E Hankinson; Karestan C Koenen; Laura D Kubzansky Journal: Psychosom Med Date: 2022-04-27 Impact factor: 3.864
Authors: Izabela Burzynska-Pedziwiatr; Adrian Jankowski; Konrad Kowalski; Przemyslaw Sendys; Andrzej Zieleniak; Katarzyna Cypryk; Monika Zurawska-Klis; Lucyna A Wozniak; Malgorzata Bukowiecka-Matusiak Journal: Int J Mol Sci Date: 2020-10-22 Impact factor: 5.923