| Literature DB >> 28641456 |
Mei-Lin Yu1,2, Fei-Fei Guan1,2, Fei Cao1,3, Yan-Lai Jia1,2, Chang-Yun Wang1,2.
Abstract
A new pregnane, 3α-hydroxy-7-ene-6,20-dione (1), and five known steroids (2-6), along with one known steroidal glycoside (7) were obtained from the fungus Cladosporium sp. WZ-2008-0042 cultured from a gorgonian Dichotella gemmacea collected from the South China Sea. The structure and absolute configuration of the new compound (1) were elucidated by comprehensive spectroscopic data and X-ray diffraction data. The compound has a rare configuration of 3α-OH that is different from most of pregnanes. All of the isolated compounds were evaluated for their antiviral activities against respiratory syncytial virus (RSV). Among them, 1 exhibited potential antiviral activity with the IC50 value of 0.12 mM.Entities:
Keywords: 3α-OH pregnane; Cladosporium sp; antiviral activity; gorgonian Dichotella gemmacea; structure elucidation
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Year: 2017 PMID： 28641456 DOI： 10.1080/14786419.2017.1342086
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861