BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating disease leading to death within 3-5 years in most cases. New approaches to treating this disease are needed. Here, we report a successful therapy. CASE REPORT: In a 49-year-old male patient suffering from muscle weakness and fasciculations, progressive muscular atrophy, a variant of ALS, was diagnosed after extensive examinations ruling out other diseases. Due to supposed mercury exposure from residual amalgam, the patient's teeth were restored. Then, the patient received sodium 2,3-dimercaptopropanesulfate (DMPS; overall 86 × 250 mg in 3 years) in combination with α-lipoic acid and followed by selenium. In addition, he took vitamins and micronutrients and kept a vegetarian diet. The excretion of metals was monitored in the urine. The success of the therapy was followed by scoring muscle weakness and fasciculations and finally by electromyography (EMG) of the affected muscles. First improvements occurred after the dental restorations. Two months after starting therapy with DMPS, the mercury level in the urine was increased (248.4 µg/g creatinine). After 1.5 years, EMG confirmed the absence of typical signs of ALS. In the course of 3 years, the patient recovered completely. CONCLUSIONS: The therapy described here is a promising approach to treating some kinds of motor neuron disease and merits further evaluation in rigorous trials.
BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a devastating disease leading to death within 3-5 years in most cases. New approaches to treating this disease are needed. Here, we report a successful therapy. CASE REPORT: In a 49-year-old male patient suffering from muscle weakness and fasciculations, progressive muscular atrophy, a variant of ALS, was diagnosed after extensive examinations ruling out other diseases. Due to supposed mercury exposure from residual amalgam, the patient's teeth were restored. Then, the patient received sodium 2,3-dimercaptopropanesulfate (DMPS; overall 86 × 250 mg in 3 years) in combination with α-lipoic acid and followed by selenium. In addition, he took vitamins and micronutrients and kept a vegetarian diet. The excretion of metals was monitored in the urine. The success of the therapy was followed by scoring muscle weakness and fasciculations and finally by electromyography (EMG) of the affected muscles. First improvements occurred after the dental restorations. Two months after starting therapy with DMPS, the mercury level in the urine was increased (248.4 µg/g creatinine). After 1.5 years, EMG confirmed the absence of typical signs of ALS. In the course of 3 years, the patient recovered completely. CONCLUSIONS: The therapy described here is a promising approach to treating some kinds of motor neuron disease and merits further evaluation in rigorous trials.
Authors: Claudia Figueroa-Romero; Kristen A Mikhail; Chris Gennings; Paul Curtin; Ghalib A Bello; Tatiana M Botero; Stephen A Goutman; Eva L Feldman; Manish Arora; Christine Austin Journal: Ann Clin Transl Neurol Date: 2020-05-21 Impact factor: 4.511
Authors: Elin Roos; Sebastian K T S Wärmländer; Jeremy Meyer; Sabrina B Sholts; Jüri Jarvet; Astrid Gräslund; Per M Roos Journal: Biol Trace Elem Res Date: 2020-11-23 Impact factor: 3.738
Authors: Polina S Goncharova; Tatiana K Davydova; Tatiana E Popova; Maxim A Novitsky; Marina M Petrova; Oksana A Gavrilyuk; Mustafa Al-Zamil; Natalia G Zhukova; Regina F Nasyrova; Natalia A Shnayder Journal: Nutrients Date: 2021-10-26 Impact factor: 5.717
Authors: Lassi Koski; Cecilia Ronnevi; Elina Berntsson; Sebastian K T S Wärmländer; Per M Roos Journal: Int J Mol Sci Date: 2021-11-11 Impact factor: 5.923