Anke Diemert1, Janina Goletzke2, Claus Barkmann3, Robert Jung4, Kurt Hecher2, Petra Arck2. 1. Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany. Electronic address: a.diemert@uke.de. 2. Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany. 3. Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Germany. 4. Center for Diagnostics, Department of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.
Abstract
OBJECTIVE: Successful pregnancy outcome is the result of a tailored adaptation of the maternal endocrine and immune system throughout gestation. We aimed to investigate if maternal endocrine, anthropometric and life style factors assessed longitudinally throughout pregnancy allow prediction of birth weight. STUDY DESIGN: Data on maternal factors and obstetrical characteristics from 220 pregnancies from a German prospective pregnancy cohort were analyzed using univariate and multivariate regression models. The association between maternal progesterone levels at the end of the 1st (gw 12-14), the 2nd (gw 22-24) and the 3rd trimester (gw 34-36) and birth weight of children born at term was examined. Interaction terms were included to identify possible sex-specific associations. Furthermore, associations between maternal and obstetric characteristics and progesterone levels were tested. RESULTS: After controlling for possible confounders, progesterone in the 2nd trimester emerged as an independent predictor for birth weight in pregnancies with female (p=0.01), but not male fetuses (p=0.6). In female fetuses each increase of progesterone by 1ng/ml in the 2nd trimester was associated with an increase of birth weight by 6.8g (95%-CI=1.44-12.24). Maternal 1st trimester BMI showed a significant inverse correlation to progesterone levels throughout gestation (p<0.0001 in the 1st and 2nd, p=0.01 in the 3rd trimester). This inverse association between maternal BMI and progesterone levels was confined to overweight women. CONCLUSION: Our data support that maternal progesterone levels have the potential to serve as early biomarker for reduced birth weight and underpins the importance of normal weight when entering the reproductive phase.
OBJECTIVE: Successful pregnancy outcome is the result of a tailored adaptation of the maternal endocrine and immune system throughout gestation. We aimed to investigate if maternal endocrine, anthropometric and life style factors assessed longitudinally throughout pregnancy allow prediction of birth weight. STUDY DESIGN: Data on maternal factors and obstetrical characteristics from 220 pregnancies from a German prospective pregnancy cohort were analyzed using univariate and multivariate regression models. The association between maternal progesterone levels at the end of the 1st (gw 12-14), the 2nd (gw 22-24) and the 3rd trimester (gw 34-36) and birth weight of children born at term was examined. Interaction terms were included to identify possible sex-specific associations. Furthermore, associations between maternal and obstetric characteristics and progesterone levels were tested. RESULTS: After controlling for possible confounders, progesterone in the 2nd trimester emerged as an independent predictor for birth weight in pregnancies with female (p=0.01), but not male fetuses (p=0.6). In female fetuses each increase of progesterone by 1ng/ml in the 2nd trimester was associated with an increase of birth weight by 6.8g (95%-CI=1.44-12.24). Maternal 1st trimester BMI showed a significant inverse correlation to progesterone levels throughout gestation (p<0.0001 in the 1st and 2nd, p=0.01 in the 3rd trimester). This inverse association between maternal BMI and progesterone levels was confined to overweight women. CONCLUSION: Our data support that maternal progesterone levels have the potential to serve as early biomarker for reduced birth weight and underpins the importance of normal weight when entering the reproductive phase.
Authors: S Hahn; P Hasler; L Vokalova; S V van Breda; O Lapaire; N G Than; I Hoesli; S W Rossi Journal: Clin Exp Immunol Date: 2019-03-13 Impact factor: 4.330
Authors: Lars Bremer; Janina Goletzke; Christian Wiessner; Mirja Pagenkemper; Christina Gehbauer; Heiko Becher; Eva Tolosa; Kurt Hecher; Petra C Arck; Anke Diemert; Gisa Tiegs Journal: EBioMedicine Date: 2017-11-09 Impact factor: 8.143
Authors: Ina Annelies Stelzer; Christopher Urbschat; Steven Schepanski; Kristin Thiele; Ioanna Triviai; Agnes Wieczorek; Malik Alawi; Denise Ohnezeit; Julian Kottlau; Jiabin Huang; Nicole Fischer; Hans-Willi Mittrücker; Maria Emilia Solano; Boris Fehse; Anke Diemert; Felix R Stahl; Petra Clara Arck Journal: Nat Commun Date: 2021-08-04 Impact factor: 14.919