OBJECTIVE: Using data from 2003-2012, we updated a previous analysis of trends in hospitalizations of HIV-infected children and adolescents in the United States. METHODS: We used data from the Kids´ Inpatient Database of the Healthcare Cost and Utilization Project to derive nationally representative estimates of the number of hospitalizations and the rates per 1000 hospitalizations of select discharge diagnoses and procedures in 2003, 2006, 2009 and 2012 among HIV-infected and HIV-uninfected children and adolescents ≤18 years, excluding hospitalizations for conditions related to pregnancy/delivery and neonatal diagnoses. We also examined trends in the prevalence of select discharge diagnoses and procedures using multivariable logistic regression models. RESULTS: During 2003-2012, the number of hospitalizations for HIV-infected children declined 58% versus 17% for uninfected, but the odds of having discharge codes for most of the diagnoses and procedures studied, including death during hospitalization, remained higher among HIV-infected compared with uninfected children. Among HIV-infected children, the prevalence of discharge diagnoses for pneumonia, pneumococcal disease and varicella/herpes zoster infections and odds of death during hospitalization decreased over time, while bacterial infections/sepsis and methicillin-resistant Staphylococcus aureus increased. Among HIV-uninfected children, there was no increase in diagnoses of bacterial infection/sepsis, but otherwise trends were similar. CONCLUSIONS: The number of hospitalizations for HIV-infected children declined from 2003 to 2012. The decreased prevalence of several discharge diagnoses and lower risk of death during hospitalization likely reflect improvements in HIV therapies and increased uptake of other preventive strategies. However, the increasing prevalence of discharge diagnoses for bacterial infections/sepsis warrants further attention and monitoring.
OBJECTIVE: Using data from 2003-2012, we updated a previous analysis of trends in hospitalizations of HIV-infectedchildren and adolescents in the United States. METHODS: We used data from the Kids´ Inpatient Database of the Healthcare Cost and Utilization Project to derive nationally representative estimates of the number of hospitalizations and the rates per 1000 hospitalizations of select discharge diagnoses and procedures in 2003, 2006, 2009 and 2012 among HIV-infected and HIV-uninfectedchildren and adolescents ≤18 years, excluding hospitalizations for conditions related to pregnancy/delivery and neonatal diagnoses. We also examined trends in the prevalence of select discharge diagnoses and procedures using multivariable logistic regression models. RESULTS: During 2003-2012, the number of hospitalizations for HIV-infectedchildren declined 58% versus 17% for uninfected, but the odds of having discharge codes for most of the diagnoses and procedures studied, including death during hospitalization, remained higher among HIV-infected compared with uninfected children. Among HIV-infectedchildren, the prevalence of discharge diagnoses for pneumonia, pneumococcal disease and varicella/herpes zoster infections and odds of death during hospitalization decreased over time, while bacterial infections/sepsis and methicillin-resistant Staphylococcus aureus increased. Among HIV-uninfectedchildren, there was no increase in diagnoses of bacterial infection/sepsis, but otherwise trends were similar. CONCLUSIONS: The number of hospitalizations for HIV-infectedchildren declined from 2003 to 2012. The decreased prevalence of several discharge diagnoses and lower risk of death during hospitalization likely reflect improvements in HIV therapies and increased uptake of other preventive strategies. However, the increasing prevalence of discharge diagnoses for bacterial infections/sepsis warrants further attention and monitoring.
Authors: Melissa K Schaefer; Katherine Ellingson; Craig Conover; Alicia E Genisca; Donna Currie; Tina Esposito; Laura Panttila; Peter Ruestow; Karen Martin; Diane Cronin; Michael Costello; Stephen Sokalski; Scott Fridkin; Arjun Srinivasan Journal: Infect Control Hosp Epidemiol Date: 2010-05 Impact factor: 3.254
Authors: Marin L Schweizer; Michael R Eber; Ramanan Laxminarayan; Jon P Furuno; Kyle J Popovich; Bala Hota; Michael A Rubin; Eli N Perencevich Journal: Infect Control Hosp Epidemiol Date: 2011-02 Impact factor: 3.254
Authors: Frances L Wong; Alice J Hsu; Paul A Pham; George K Siberry; Nancy Hutton; Allison L Agwu Journal: Pediatr Infect Dis J Date: 2012-12 Impact factor: 2.129
Authors: Lynne M Mofenson; Michael T Brady; Susie P Danner; Kenneth L Dominguez; Rohan Hazra; Edward Handelsman; Peter Havens; Steve Nesheim; Jennifer S Read; Leslie Serchuck; Russell Van Dyke Journal: MMWR Recomm Rep Date: 2009-09-04
Authors: Nathan Ford; Zara Shubber; Graeme Meintjes; Beatriz Grinsztejn; Serge Eholie; Edward J Mills; Mary-Ann Davies; Marco Vitoria; Martina Penazzato; Sabin Nsanzimana; Lisa Frigati; Daniel O'Brien; Tom Ellman; Olawale Ajose; Alexandra Calmy; Meg Doherty Journal: Lancet HIV Date: 2015-08-11 Impact factor: 12.767