Antonio Corvino1,2,3, Orlando Catalano3, Fabio Corvino4, Fabio Sandomenico3, Antonella Petrillo3. 1. 1 Department of Radiology, University of Naples Parthenope, Naples, Italy. 2. 2 Via B, Croce n. 82, 81033 Casal di Principe (CE), Italy. 3. 3 Department of Radiology, National Cancer Institute, Pascale Foundation, Naples, Italy. 4. 4 Department of Advanced Medical Biosciences, University Federico II of Naples, Naples, Italy.
Abstract
OBJECTIVE: The aims of this study were to assess the diagnostic performance of contrast-enhanced ultrasound (CEUS) in the characterization of atypical cystic and cysticlike focal liver lesions in comparison with conventional US and to determine whether the use of CEUS can reduce the need for further diagnostic workup. SUBJECTS AND METHODS: In a 3-year period 48 patients with 50 atypical cystic and cysticlike lesions found at conventional US underwent CEUS. Diagnostic confirmation was obtained in cytohistopathologic examinations, with other imaging modalities, and in follow-up. Overall, there were 24 cystic lesions and 26 cysticlike solid lesions, specifically 32 benign and 18 malignant lesions. The conventional US and CEUS images and cine loops were reviewed by two blinded readers independently. Sensitivity, specificity, area under the ROC curve (Az), and interobserver agreement were calculated. RESULTS: Diagnostic performance improved after review of CEUS examinations by both readers (conventional US Az = 0.781 vs 0.972; CEUS Az = 0.734 vs 0.957). Interreader agreement increased, although slightly (conventional US weighted κ = 0.894; CEUS weighted κ = 0.953). In terms of differential diagnosis, the occurrence of correctly characterized lesions increased after CEUS for both readers (reader 1, 62% to 98%; reader 2, 56% to 96%). CONCLUSION: The development of low-acoustic-power CEUS has made it possible to identify several imaging features of cystic and cysticlike focal liver lesions that, in association with history and clinical findings, may help to correctly characterize them. Our data indicate the usefulness of CEUS in the evaluation of patients with these lesions.
OBJECTIVE: The aims of this study were to assess the diagnostic performance of contrast-enhanced ultrasound (CEUS) in the characterization of atypical cystic and cysticlike focal liver lesions in comparison with conventional US and to determine whether the use of CEUS can reduce the need for further diagnostic workup. SUBJECTS AND METHODS: In a 3-year period 48 patients with 50 atypical cystic and cysticlike lesions found at conventional US underwent CEUS. Diagnostic confirmation was obtained in cytohistopathologic examinations, with other imaging modalities, and in follow-up. Overall, there were 24 cystic lesions and 26 cysticlike solid lesions, specifically 32 benign and 18 malignant lesions. The conventional US and CEUS images and cine loops were reviewed by two blinded readers independently. Sensitivity, specificity, area under the ROC curve (Az), and interobserver agreement were calculated. RESULTS: Diagnostic performance improved after review of CEUS examinations by both readers (conventional US Az = 0.781 vs 0.972; CEUS Az = 0.734 vs 0.957). Interreader agreement increased, although slightly (conventional US weighted κ = 0.894; CEUS weighted κ = 0.953). In terms of differential diagnosis, the occurrence of correctly characterized lesions increased after CEUS for both readers (reader 1, 62% to 98%; reader 2, 56% to 96%). CONCLUSION: The development of low-acoustic-power CEUS has made it possible to identify several imaging features of cystic and cysticlike focal liver lesions that, in association with history and clinical findings, may help to correctly characterize them. Our data indicate the usefulness of CEUS in the evaluation of patients with these lesions.
Authors: Francesco Giurazza; Fabio Corvino; Andrea Contegiacomo; Paolo Marra; Nicola Maria Lucarelli; Marco Calandri; Mattia Silvestre; Antonio Corvino; Pierleone Lucatelli; Francesco De Cobelli; Raffaella Niola; Maurizio Cariati Journal: J Ultrasound Date: 2019-07-31
Authors: P Lomoro; I Simonetti; A L Nanni; G Corsani; G Togni; V Fichera; F Verde; M Formica; P Trovato; G Vallone; M S Prevedoni Gorone Journal: J Ultrasound Date: 2020-03-05
Authors: Antonio Corvino; Dario De Rosa; Carolina Sbordone; Antonio Nunziata; Fabio Corvino; Carlo Varelli; Orlando Catalano Journal: Pol J Radiol Date: 2019-12-15