Martin Tonglet1, Rolf Lefering2, Jean Marc Minon3, Alexandre Ghuysen1, Vincenzo D'Orio1, Frank Hildebrand4, Hans-Christoph Pape4, Klemens Horst4. 1. a Department of Emergency , Liege University Hospital, Domaine du Sart Tilman , Liege , Belgium. 2. b Department of Medicine, Institute for Research in Operative Medicine (IFOM), Faculty of Health , Witten/Herdecke University , Cologne , Germany. 3. c Department of Laboratory and Transfusion , CHR de la Citadelle , Liege , Belgium. 4. d Department of Orthopedic Trauma , RWTH Aachen University Hospital , Aachen , Germany.
Abstract
BACKGROUND: Identifying trauma patients that need emergent blood product transfusion is crucial. The Trauma Induced Coagulopathy Clinical Score (TICCS) is an easy-to-measure score developed to meet this medical need. We hypothesized that TICCS would assist in identifying patients that need a transfusion in a large cohort of severe trauma patients from the TraumaRegister DGU® (TR-DGU). MATERIALS AND METHODS: A total of 33,385 severe trauma patients were extracted from the TR-DGU for retrospective analysis. The TICCS was adapted for the registry structure. Blood transfusion was defined as the use of at least one unit of red blood cells (RBC) during acute hospital treatment. RESULTS: With an area under the receiving operating curve (AUC) of 0.700 (95% CI: 0.691-0.709), the TICCS appeared to be moderately discriminant for determining the need for RBC transfusion in the trauma population of the TR-DGU. A TICCS cut-off value of ≥12 yielded the best trade-off between true positives and false positives. The corresponding positive predictive value and negative predictive values were 48.4% and 89.1%, respectively. CONCLUSION: This retrospective study confirms that the TICCS is a useful and simple score for discriminating between trauma patients with and without the need for emergent blood product transfusion.
BACKGROUND: Identifying traumapatients that need emergent blood product transfusion is crucial. The Trauma Induced Coagulopathy Clinical Score (TICCS) is an easy-to-measure score developed to meet this medical need. We hypothesized that TICCS would assist in identifying patients that need a transfusion in a large cohort of severe traumapatients from the TraumaRegister DGU® (TR-DGU). MATERIALS AND METHODS: A total of 33,385 severe traumapatients were extracted from the TR-DGU for retrospective analysis. The TICCS was adapted for the registry structure. Blood transfusion was defined as the use of at least one unit of red blood cells (RBC) during acute hospital treatment. RESULTS: With an area under the receiving operating curve (AUC) of 0.700 (95% CI: 0.691-0.709), the TICCS appeared to be moderately discriminant for determining the need for RBC transfusion in the trauma population of the TR-DGU. A TICCS cut-off value of ≥12 yielded the best trade-off between true positives and false positives. The corresponding positive predictive value and negative predictive values were 48.4% and 89.1%, respectively. CONCLUSION: This retrospective study confirms that the TICCS is a useful and simple score for discriminating between traumapatients with and without the need for emergent blood product transfusion.
Entities:
Keywords:
bleeding; transfusion; trauma; trauma-scoring systems
Authors: Klemens Horst; Philipp Lichte; Felix Bläsius; Christian David Weber; Martin Tonglet; Philipp Kobbe; Nicole Heussen; Frank Hildebrand Journal: Eur J Trauma Emerg Surg Date: 2020-10-14 Impact factor: 3.693
Authors: Klemens Horst; Rachel Lentzen; Martin Tonglet; Ümit Mert; Philipp Lichte; Christian D Weber; Philipp Kobbe; Nicole Heussen; Frank Hildebrand Journal: J Clin Med Date: 2020-03-30 Impact factor: 4.241