Literature DB >> 28639090

Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination.

Raymond Liang1,2, Saghi Ghaffari3,4,5,6.   

Abstract

The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate that FOXO3 is implicated in the control of mitochondrial function beyond regulating levels of ROS in HSC. Here we review these findings and discuss implications for homeostatic blood formation and stem cell fate determination.

Entities:  

Keywords:  FOXO; FOXO3; HSC; Mitochondria; ROS; Stem cell; UPR

Mesh：

Substances：

Year:  2017        PMID： 28639090      PMCID： PMC6623966          DOI： 10.1007/s10863-017-9719-7

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  49 in total

1.  The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells.

Authors:  Maria Maryanovich; Galia Oberkovitz; Hagit Niv; Lidiya Vorobiyov; Yehudit Zaltsman; Ori Brenner; Tsvee Lapidot; Steffen Jung; Atan Gross
Journal:  Nat Cell Biol       Date:  2012-03-25       Impact factor: 28.824

2.  The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

Authors:  Sushma Gurumurthy; Stephanie Z Xie; Brinda Alagesan; Judith Kim; Rushdia Z Yusuf; Borja Saez; Alexandros Tzatsos; Fatih Ozsolak; Patrice Milos; Francesco Ferrari; Peter J Park; Orian S Shirihai; David T Scadden; Nabeel Bardeesy
Journal:  Nature       Date:  2010-12-02       Impact factor: 49.962

3.  daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

Authors:  K Lin; J B Dorman; A Rodan; C Kenyon
Journal:  Science       Date:  1997-11-14       Impact factor: 47.728

4.  Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells.

Authors:  Fatih Kocabas; Junke Zheng; Suwannee Thet; Neal G Copeland; Nancy A Jenkins; Ralph J DeBerardinis; Chengcheng Zhang; Hesham A Sadek
Journal:  Blood       Date:  2012-09-20       Impact factor: 22.113

5.  Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.

Authors:  Geert J P L Kops; Tobias B Dansen; Paulien E Polderman; Ingrid Saarloos; Karel W A Wirtz; Paul J Coffer; Ting-T Huang; Johannes L Bos; René H Medema; Boudewijn M T Burgering
Journal:  Nature       Date:  2002-09-19       Impact factor: 49.962

6.  Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Authors:  Anne Brunet; Lora B Sweeney; J Fitzhugh Sturgill; Katrin F Chua; Paul L Greer; Yingxi Lin; Hien Tran; Sarah E Ross; Raul Mostoslavsky; Haim Y Cohen; Linda S Hu; Hwei-Ling Cheng; Mark P Jedrychowski; Steven P Gygi; David A Sinclair; Frederick W Alt; Michael E Greenberg
Journal:  Science       Date:  2004-02-19       Impact factor: 47.728

7.  SIRT3 reverses aging-associated degeneration.

Authors:  Katharine Brown; Stephanie Xie; Xiaolei Qiu; Mary Mohrin; Jiyung Shin; Yufei Liu; Dan Zhang; David T Scadden; Danica Chen
Journal:  Cell Rep       Date:  2013-01-31       Impact factor: 9.423

8.  A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche.

Authors:  Yoon-Young Jang; Saul J Sharkis
Journal:  Blood       Date:  2007-06-26       Impact factor: 22.113

9.  Mammalian SIRT1 represses forkhead transcription factors.

Authors:  Maria Carla Motta; Nullin Divecha; Madeleine Lemieux; Christopher Kamel; Delin Chen; Wei Gu; Yvette Bultsma; Michael McBurney; Leonard Guarente
Journal:  Cell       Date:  2004-02-20       Impact factor: 41.582

10.  Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.

Authors:  Daisuke Nakada; Thomas L Saunders; Sean J Morrison
Journal:  Nature       Date:  2010-12-02       Impact factor: 49.962
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  12 in total

Review 1.  Hematopoietic stem cell fate through metabolic control.

Authors:  Kyoko Ito; Keisuke Ito
Journal:  Exp Hematol       Date:  2018-05-25       Impact factor: 3.084

Review 2.  The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology.

Authors:  Catherine J Libby; Jonathan McConathy; Victor Darley-Usmar; Anita B Hjelmeland
Journal:  Cancer Res       Date:  2019-10-01       Impact factor: 12.701

Review 3.  Transcription factors FOXO in the regulation of homeostatic hematopoiesis.

Authors:  Vijay Menon; Saghi Ghaffari
Journal:  Curr Opin Hematol       Date:  2018-07       Impact factor: 3.284

Review 4.  Dynamic regulation of mitochondrial-endoplasmic reticulum crosstalk during stem cell homeostasis and aging.

Authors:  Weiping Lin; Shuxun Chen; Yan Wang; Ming Wang; Wayne Yuk-Wai Lee; Xiaohua Jiang; Gang Li
Journal:  Cell Death Dis       Date:  2021-08-16       Impact factor: 8.469

5.  Novel Functional, Health, and Genetic Determinants of Cognitive Terminal Decline: Kuakini Honolulu Heart Program/Honolulu-Asia Aging Study.

Authors:  Jennifer A Margrett; Thomas Schofield; Peter Martin; Leonard W Poon; Kamal Masaki; Timothy A Donlon; Kalpana J Kallianpur; Bradley J Willcox
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2022-08-12       Impact factor: 6.591

6.  Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging.

Authors:  Abhishek K Singh; Mark J Althoff; Jose A Cancelas
Journal:  Curr Stem Cell Rep       Date:  2018-05-01

7.  Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway.

Authors:  Yujie Huang; Xiaohui Zhu; Ka Chen; Hedong Lang; Yong Zhang; Pengfei Hou; Li Ran; Min Zhou; Jiawei Zheng; Long Yi; Mantian Mi; Qianyong Zhang
Journal:  Aging (Albany NY)       Date:  2019-04-15       Impact factor: 5.682

Review 8.  Oxidative Stress and ROS-Mediated Signaling in Leukemia: Novel Promising Perspectives to Eradicate Chemoresistant Cells in Myeloid Leukemia.

Authors:  Silvia Trombetti; Elena Cesaro; Rosa Catapano; Raffaele Sessa; Alessandra Lo Bianco; Paola Izzo; Michela Grosso
Journal:  Int J Mol Sci       Date:  2021-02-28       Impact factor: 5.923

9.  Interleukin4Rα (IL4Rα) and IL13Rα1 Are Associated with the Progress of Renal Cell Carcinoma through Janus Kinase 2 (JAK2)/Forkhead Box O3 (FOXO3) Pathways.

Authors:  Mi-Ae Kang; Jongsung Lee; Sang Hoon Ha; Chang Min Lee; Kyoung Min Kim; Kyu Yun Jang; See-Hyoung Park
Journal:  Cancers (Basel)       Date:  2019-09-18       Impact factor: 6.639

Review 10.  A New Vision of Mitochondrial Unfolded Protein Response to the Sirtuin Family.

Authors:  Huidan Weng; Yihong Ma; Lina Chen; Guoen Cai; Zhiting Chen; Shaochuan Zhang; Qinyong Ye
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363
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