José Boto1, Georgios Gkinis2, Alexis Roche3,4,5, Tobias Kober3,4,5, Bénédicte Maréchal3,4,5, Nadia Ortiz2, Karl-Olof Lövblad6, François Lazeyras7, Maria Isabel Vargas6. 1. Division of Neuroradiology, Geneva University Hospital and Faculty of Medicine of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland. jose.m.baiaoboto@hcuge.ch. 2. Department of Mental Health and Psychiatry, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland. 3. Advanced Clinical Imaging Technology, Siemens Healthcare HC CEMEA SUI DI BM PI, Siemens ACIT, EPFL QI-E 4 126, 1015, Lausanne, Switzerland. 4. Department of Radiology, University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland. 5. , LTS5, École Polytechnique Fédérale de Lausanne, Route Cantonale, 1015, Lausanne, Switzerland. 6. Division of Neuroradiology, Geneva University Hospital and Faculty of Medicine of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland. 7. Division of Radiology, Geneva University Hospital and Faculty of Medicine of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Abstract
AIM: To evaluate brain atrophy in anorexic patients by automated cerebral segmentation with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence. MATERIAL AND METHODS: Twenty patients (female; mean age, 27.9 years), presenting consecutively for brain MRI between August 2014-December 2016 with clinical suspicion of anorexia nervosa and BMI<18.5 kg/m2 were included. Controls were ten healthy females (mean age, 26.5 years). Automated brain morphometry was performed based on MP2RAGE. Means of morphometric results in the two groups were compared and correlation with BMI was analysed. RESULTS: Significantly lower volumes of total brain, grey matter (GM), white matter (WM), cerebellum and insula were found in anorexic patients. Anorexics had higher volumes of CSF, ventricles, lateral ventricles and third ventricle. When adjusted means for weight and height were compared, the volume of WM and cerebellum were not significantly different. However, volume of WM was significantly affected by weight and positively correlated with BMI. Significant positive correlations were found between BMI and volumes of total brain, GM, cortical GM and WM. BMI was negatively correlated with volumes of CSF and third ventricle. CONCLUSION: Brain atrophy was demonstrated in anorexic patients with MP2RAGE-based automated segmentation, which seems to reliably estimate brain volume. KEY POINTS: • Automated brain segmentation based on 3-D MRI seems to reliably estimate brain volume. • This technique detected brain atrophy in patients suffering from anorexia nervosa. • Brain changes in anorexia nervosa can be quantitatively and qualitatively followed-up by MRI.
AIM: To evaluate brain atrophy in anorexic patients by automated cerebral segmentation with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence. MATERIAL AND METHODS: Twenty patients (female; mean age, 27.9 years), presenting consecutively for brain MRI between August 2014-December 2016 with clinical suspicion of anorexia nervosa and BMI<18.5 kg/m2 were included. Controls were ten healthy females (mean age, 26.5 years). Automated brain morphometry was performed based on MP2RAGE. Means of morphometric results in the two groups were compared and correlation with BMI was analysed. RESULTS: Significantly lower volumes of total brain, grey matter (GM), white matter (WM), cerebellum and insula were found in anorexic patients. Anorexics had higher volumes of CSF, ventricles, lateral ventricles and third ventricle. When adjusted means for weight and height were compared, the volume of WM and cerebellum were not significantly different. However, volume of WM was significantly affected by weight and positively correlated with BMI. Significant positive correlations were found between BMI and volumes of total brain, GM, cortical GM and WM. BMI was negatively correlated with volumes of CSF and third ventricle. CONCLUSION:Brain atrophy was demonstrated in anorexic patients with MP2RAGE-based automated segmentation, which seems to reliably estimate brain volume. KEY POINTS: • Automated brain segmentation based on 3-D MRI seems to reliably estimate brain volume. • This technique detected brain atrophy in patients suffering from anorexia nervosa. • Brain changes in anorexia nervosa can be quantitatively and qualitatively followed-up by MRI.
Entities:
Keywords:
3-D imaging; Anorexia nervosa; Atrophy; Brain; Magnetic resonance imaging
Authors: Daniel-Paolo Streitbürger; André Pampel; Gunnar Krueger; Jöran Lepsien; Matthias L Schroeter; Karsten Mueller; Harald E Möller Journal: Neuroimage Date: 2013-11-02 Impact factor: 6.556
Authors: Mark Mühlau; Christian Gaser; Rüdiger Ilg; Bastian Conrad; Carl Leibl; Marian H Cebulla; Herbert Backmund; Monika Gerlinghoff; Peter Lommer; Andreas Schnebel; Afra M Wohlschläger; Claus Zimmer; Sabine Nunnemann Journal: Am J Psychiatry Date: 2007-12 Impact factor: 18.112
Authors: Alice Regnaud; José Boto; Antoine Klauser; Karl-Olof Lövblad; Maria Isabel Vargas; François Lazeyras Journal: J Neuroimaging Date: 2021-08-31 Impact factor: 2.324
Authors: Pratik Kashyap; Trey E Shenk; Diana O Svaldi; Roy J Lycke; Taylor A Lee; Gregory G Tamer; Eric A Nauman; Thomas M Talavage Journal: Neurotrauma Rep Date: 2022-01-28