Literature DB >> 28638843

Susceptibility to Cryptococcal Meningoencephalitis Associated With Idiopathic CD4+ Lymphopenia and Secondary Germline or Acquired Defects.

Anil A Panackal1,2, Lindsey B Rosen1, Gulbu Uzel1, Michael J Davis1, Guowu Hu1, Adebowale Adeyemo3, Fasil Tekola-Ayele4, Andrea Lisco5, Christopher Diachok1, Jonathan D Kim1, Dawn Shaw6, Irini Sereti5, Jennifer Stoddard7, Julie Niemela7, Sergio D Rosenzweig7, John E Bennett1,2, Peter R Williamson1.   

Abstract

Idiopathic CD4+ lymphopenia (ICL) predisposes to opportunistic infections (OIs) but can often remain asymptomatic and does not have a strong association with monogenic mutations. Likewise, cryptococcal meningoencephalitis, the most common OI in ICL, is not strongly associated with monogenic mutations. In this study, we describe 2 patients with ICL plus an additional immune defect: one from an E57K genetic mutation in the nuclear factor-κβ essential modulator, and the other with acquired autoantibodies to granulocyte-macrophage colony-stimulating factor. Thus, these cases may exemplify a "multi-hit model" in patients with ICL who acquire OIs.

Entities:  

Keywords:  Cryptococcus; autoantibody; idiopathic CD4+ lymphopenia.; meningoencephalitis

Year:  2017        PMID： 28638843      PMCID： PMC5461987          DOI： 10.1093/ofid/ofx082

Source DB:  PubMed          Journal:  Open Forum Infect Dis        ISSN： 2328-8957            Impact factor:   3.835


  15 in total

Review 1.  Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia.

Authors:  Magdalena M Gorska; Rafeul Alam
Journal:  Curr Allergy Asthma Rep       Date:  2012-10       Impact factor: 4.806

2.  Identification of a new NEMO/TRAF6 interface affected in incontinentia pigmenti pathology.

Authors:  Jérémie Gautheron; Alessandra Pescatore; Francesca Fusco; Elio Esposito; Shoji Yamaoka; Fabrice Agou; Matilde Valeria Ursini; Gilles Courtois
Journal:  Hum Mol Genet       Date:  2010-06-07       Impact factor: 6.150

3.  Modulation of Macrophage Inflammatory Nuclear Factor κB (NF-κB) Signaling by Intracellular Cryptococcus neoformans.

Authors:  James B Hayes; Linda M Sircy; Lauren E Heusinkveld; Wandi Ding; Rachel N Leander; Erin E McClelland; David E Nelson
Journal:  J Biol Chem       Date:  2016-05-26       Impact factor: 5.157

4.  DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.

Authors:  Alexandre Bignon; Alexis Régent; Laurence Klipfel; Aude Desnoyer; Pierre de la Grange; Valérie Martinez; Olivier Lortholary; Ali Dalloul; Luc Mouthon; Karl Balabanian
Journal:  Blood       Date:  2015-03-02       Impact factor: 22.113

5.  Cryptococcosis and idiopathic CD4 lymphocytopenia.

Authors:  Dimitrios I Zonios; Judith Falloon; Chiung-Yu Huang; Doreen Chaitt; John E Bennett
Journal:  Medicine (Baltimore)       Date:  2007-03       Impact factor: 1.889

6.  Cutting edge: TCR ligation triggers digital activation of NF-kappaB.

Authors:  Lara M Kingeter; Suman Paul; Sean K Maynard; Natalia G Cartwright; Brian C Schaefer
Journal:  J Immunol       Date:  2010-09-20       Impact factor: 5.422

7.  Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States.

Authors:  Edmond J Byrnes; Wenjun Li; Yonathan Lewit; Hansong Ma; Kerstin Voelz; Ping Ren; Dee A Carter; Vishnu Chaturvedi; Robert J Bildfell; Robin C May; Joseph Heitman
Journal:  PLoS Pathog       Date:  2010-04-22       Impact factor: 6.823

Review 8.  Unexplained opportunistic infections and CD4+ T-lymphocytopenia without HIV infection. An investigation of cases in the United States. The Centers for Disease Control Idiopathic CD4+ T-lymphocytopenia Task Force.

Authors:  D K Smith; J J Neal; S D Holmberg
Journal:  N Engl J Med       Date:  1993-02-11       Impact factor: 91.245

9.  Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis.

Authors:  Lindsey B Rosen; Alexandra F Freeman; Lauren M Yang; Kamonwan Jutivorakool; Kenneth N Olivier; Nasikarn Angkasekwinai; Yupin Suputtamongkol; John E Bennett; Vasilios Pyrgos; Peter R Williamson; Li Ding; Steven M Holland; Sarah K Browne
Journal:  J Immunol       Date:  2013-03-18       Impact factor: 5.422

10.  Resolution of Disease Phenotypes Resulting from Multilocus Genomic Variation.

Authors:  Jennifer E Posey; Tamar Harel; Pengfei Liu; Jill A Rosenfeld; Regis A James; Zeynep H Coban Akdemir; Magdalena Walkiewicz; Weimin Bi; Rui Xiao; Yan Ding; Fan Xia; Arthur L Beaudet; Donna M Muzny; Richard A Gibbs; Eric Boerwinkle; Christine M Eng; V Reid Sutton; Chad A Shaw; Sharon E Plon; Yaping Yang; James R Lupski
Journal:  N Engl J Med       Date:  2016-12-07       Impact factor: 91.245
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  12 in total

Review 1.  What Is a Host? Attributes of Individual Susceptibility.

Authors:  Arturo Casadevall; Liise-Anne Pirofski
Journal:  Infect Immun       Date:  2018-01-22       Impact factor: 3.441

Review 2.  Pathogen and host genetics underpinning cryptococcal disease.

Authors:  Carolina Coelho; Rhys A Farrer
Journal:  Adv Genet       Date:  2020-03-18       Impact factor: 3.880

3.  Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis.

Authors:  Soma Rohatgi; Antonio Nakouzi; Leandro J Carreño; Magdalena Slosar-Cheah; Mark H Kuniholm; Tao Wang; Peter G Pappas; Liise-Anne Pirofski
Journal:  Open Forum Infect Dis       Date:  2017-11-18       Impact factor: 3.835

4.  Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections.

Authors:  Nancy F Crum-Cianflone; Pamela V Lam; Sarah Ross-Walker; Lindsey B Rosen; Steven M Holland
Journal:  Open Forum Infect Dis       Date:  2017-10-05       Impact factor: 3.835

5.  Immune-Mediated Damage Completes the Parabola: Cryptococcus neoformans Pathogenesis Can Reflect the Outcome of a Weak or Strong Immune Response.

Authors:  Liise-Anne Pirofski; Arturo Casadevall
Journal:  mBio       Date:  2017-12-12       Impact factor: 7.867

Review 6.  Immunology of Cryptococcal Infections: Developing a Rational Approach to Patient Therapy.

Authors:  Waleed Elsegeiny; Kieren A Marr; Peter R Williamson
Journal:  Front Immunol       Date:  2018-04-04       Impact factor: 7.561

7.  In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host.

Authors:  A Launay; C-J Wu; A Dulanto Chiang; J-H Youn; P P Khil; J P Dekker
Journal:  Nat Commun       Date:  2021-07-23       Impact factor: 14.919

8.  Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection.

Authors:  Dong-Hoon Yang; Matthew R England; Helene Salvator; Seher Anjum; Yoon-Dong Park; Kieren A Marr; Laurie A Chu; Nelesh P Govender; Shawn R Lockhart; Marie Desnos-Ollivier; Sharon Chen; Catriona Halliday; Alex Kan; Jianghan Chen; Kurt R Wollenberg; Adrian Zelazny; John R Perfect; Yun C Chang; John E Bennett; Steven M Holland; Wieland Meyer; Peter R Williamson; Kyung J Kwon-Chung
Journal:  mBio       Date:  2021-10-26       Impact factor: 7.867

9.  Clinical Aspects of Immune Damage in Cryptococcosis.

Authors:  Seher Anjum; Peter R Williamson
Journal:  Curr Fungal Infect Rep       Date:  2019-07-22

10.  Antibody Responses in HIV-Infected Patients With Advanced Immunosuppression and Asymptomatic Cryptococcal Antigenemia.

Authors:  Admire Hlupeni; Antonio Nakouzi; Tao Wang; Kathryn F Boyd; Tariro A Makadzange; Chiratidzo E Ndhlovu; Liise-Anne Pirofski
Journal:  Open Forum Infect Dis       Date:  2018-12-11       Impact factor: 3.835
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