Ayse Betul Ergul1, Serife Cetin2, Yasemin Ay Altintop3, Sefika Elmas Bozdemir4, Alper Ozcan1, Umit Altug1, Hasan Samsa1, Yasemin Altuner Torun1. 1. Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey. 2. Department of Infection Control, Kayseri Training and Research Hospital, Kayseri, Turkey. 3. Department of Microbiology, Kayseri Training and Research Hospital, Kayseri, Turkey. 4. Department of Pediatric Infectious Diseases, Kayseri Training and Research Hospital, Kayseri, Turkey.
Abstract
OBJECTIVE: The aim of this study was to identify microorganisms causing ventilator-associated pneumonia (VAP) and also study the antibiotic resistance/susceptibility. MATERIALS AND METHODS: We retrospectively assessed microorganisms isolated from patients diagnosed with VAP in a pediatric intensive care unit between January 1, 2014, and June 30, 2016. RESULTS: We included 44 patients diagnosed with VAP. The prevalence thereof was 8.6 patients per 1,000 ventilator days. Mechanical ventilation was required for 56.5% of patients. Thirty-three patients (75%) died. An underlying chronic disease was detected in 75% of patients (n=33). Fifty microorganisms were isolated from 44 patients. Single microorganisms were isolated from 86.4% (n=38) and two from 13.6% (n=6) of patients. Of all the isolated bacteria, 96% (n=48) were gram-negative; the most common was Pseudomonas aeruginosa (32%), followed by Klebsiella pneumoniae (24%) and Acinetobacter baumannii (22%). The isolates were most susceptible to colistin (92.6%), followed by piperacillin-tazobactam (71.4%), amikacin (65.2%), and gentamicin (52.2%). No enterobacterium or Acinetobacter strain was resistant to colistin; however, 13% of P. aeruginosa isolates were resistant. CONCLUSION: In VAP, it is essential to catalog antibiotic resistance patterns of bacteria present in the unit to ensure that empirical antibiotic therapy is effective.
OBJECTIVE: The aim of this study was to identify microorganisms causing ventilator-associated pneumonia (VAP) and also study the antibiotic resistance/susceptibility. MATERIALS AND METHODS: We retrospectively assessed microorganisms isolated from patients diagnosed with VAP in a pediatric intensive care unit between January 1, 2014, and June 30, 2016. RESULTS: We included 44 patients diagnosed with VAP. The prevalence thereof was 8.6 patients per 1,000 ventilator days. Mechanical ventilation was required for 56.5% of patients. Thirty-three patients (75%) died. An underlying chronic disease was detected in 75% of patients (n=33). Fifty microorganisms were isolated from 44 patients. Single microorganisms were isolated from 86.4% (n=38) and two from 13.6% (n=6) of patients. Of all the isolated bacteria, 96% (n=48) were gram-negative; the most common was Pseudomonas aeruginosa (32%), followed by Klebsiella pneumoniae (24%) and Acinetobacter baumannii (22%). The isolates were most susceptible to colistin (92.6%), followed by piperacillin-tazobactam (71.4%), amikacin (65.2%), and gentamicin (52.2%). No enterobacterium or Acinetobacter strain was resistant to colistin; however, 13% of P. aeruginosa isolates were resistant. CONCLUSION: In VAP, it is essential to catalog antibiotic resistance patterns of bacteria present in the unit to ensure that empirical antibiotic therapy is effective.
Entities:
Keywords:
Ventilator-associated pneumonia; antibiotic; microorganism; pediatric intensive care
Authors: Michael T Bigham; Rick Amato; Pattie Bondurrant; Jon Fridriksson; Catherine D Krawczeski; Jenni Raake; Sue Ryckman; Steve Schwartz; Julie Shaw; Dan Wells; Richard J Brilli Journal: J Pediatr Date: 2008-12-03 Impact factor: 4.406
Authors: S Mladenovic-Antic; B Kocic; R Velickovic-Radovanovic; M Dinic; J Petrovic; G Randjelovic; R Mitic Journal: J Clin Pharm Ther Date: 2016-08-11 Impact factor: 2.512