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Literature DB >> 2863779

Animal models for predicting clinical efficacy of anxiolytic drugs: social behaviour.

Abstract

The behavioural, physiological and pharmacological validation of one animal test of anxiety, the social interaction test, is described in detail. The effects of anxiolytic and anxiogenic drugs, and manipulations of catecholaminergic and serotonergic pathways are considered. The test is able to distinguish anxiolytic from sedative effects and is not sensitive to the actions of antidepressants or neuroleptics.

Entities: Disease

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Year: 1985 PMID： 2863779 DOI： 10.1159/000118163

Source DB: PubMed Journal: Neuropsychobiology ISSN： 0302-282X Impact factor: 2.328

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Cited

21 in total

Review 1. Use of the "partition" test in behavioral and pharmacological experiments.

Authors: N N Kudryavtseva
Journal: Neurosci Behav Physiol Date: 2003-06

2. Species differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action.

Authors: A Fernández-Guasti; E Hong; C López-Rubalcava
Journal: Psychopharmacology (Berl) Date: 1992 Impact factor: 4.530

Animal models for predicting clinical efficacy of anxiolytic drugs: social behaviour.

Review 1. Use of the "partition" test in behavioral and pharmacological experiments.

2. Species differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action.

3. Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection.

4. Effects of milnacipran in animal models of anxiety and memory.

5. Actions of the beta-carboline ZK 93426 in an animal test of anxiety and the holeboard: interactions with Ro 15-1788.

Review 6. The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development.

Review 7. Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls.

8. The effects of triazolobenzodiazepines in two animal tests of anxiety and in the holeboard.

9. 5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model.

10. Behavioural assays to model cognitive and affective dimensions of depression and anxiety in rats.