| Literature DB >> 28636362 |
Katharina J Hock1,2, Renè Hommelsheim1, Lucas Mertens1, Junming Ho3, Thanh V Nguyen2, Rene M Koenigs1,2.
Abstract
Trifluoromethyl-substituted cyclopropanes are an attractive family of building blocks for the construction of pharmaceutical and agrochemical agents. This work demonstrated the utilization of fluorinated sulfur ylides as versatile reagents for Corey-Chaykovsky cyclopropanation reactions of nitro styrenes. This protocol favored the synthesis of cis-configured trifluoromethyl cyclopropanes for a broad range of substrates with excellent yields and good diastereoselectivities.Entities:
Year: 2017 PMID： 28636362 DOI： 10.1021/acs.joc.7b00951
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354