| Literature DB >> 28633019 |
Michiko Sekiya1, Akiko Maruko-Otake2, Stephen Hearn3, Yasufumi Sakakibara4, Naoki Fujisaki5, Emiko Suzuki6, Kanae Ando7, Koichi M Iijima8.
Abstract
The unfolded protein response (UPR), which protects cells against accumulation of misfolded proteins in the ER, is induced in several age-associated degenerative diseases. However, sustained UPR activation has negative effects on cellular functions and may worsen disease symptoms. It remains unknown whether and how UPR components can be utilized to counteract chronic ER proteinopathies. We found that promotion of ER-associated degradation (ERAD) through upregulation of ERAD-enhancing α-mannosidase-like proteins (EDEMs) protected against chronic ER proteinopathy without inducing toxicity in a Drosophila model. ERAD activity in the brain decreased with aging, and upregulation of EDEMs suppressed age-dependent behavioral decline and extended the lifespan without affecting the UPR gene expression network. Intriguingly, EDEM mannosidase activity was dispensable for these protective effects. Therefore, upregulation of EDEM function in the ERAD protects against ER proteinopathy in vivo and thus represents a potential therapeutic target for chronic diseases.Entities:
Keywords: Drosophila; EDEMs; ER stress; ER-associated degradation; ERAD; ERAD-enhancing α-mannosidase-like proteins; UPR; aging; neurodegeneration; protein misfolding; unfolded protein response
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Year: 2017 PMID： 28633019 PMCID： PMC5559287 DOI： 10.1016/j.devcel.2017.05.019
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270