Myongsoon Sung1, Kyung Suk Lee2, Eun Gyo Ha2, Seung Jin Lee2, Mi Ae Kim3, Seung Won Lee4, Hye Mi Jee2, Youn Ho Sheen5, Young Ho Jung2, Man Yong Han2. 1. Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea. 2. Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. 3. Department of Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. 4. CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. 5. Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
Abstract
BACKGROUND: Serum periostin might be a biomarker in the pathogenesis of T helper 2-type allergic diseases. The aim of this study was to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis (AD) in children. METHODS: This population-based study examined 4076 children aged 4 to 13 years between June 2015 and July 2015. Of the 4076 children, 196-137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control (HC) group-were included for the final analysis. RESULTS: Serum periostin levels were higher in the AD group than in the HC group (P<.001) and were found to be positively associated with SCORAD score (Spearman's rho [r]=.24, P=.001). Children with AD-onset time <2 years had significantly higher periostin levels (P=.030) compared to those with AD-onset time ≥2 years. The total eosinophil (P=.189) and IgE levels (P=.140) were comparable between children with AD-onset time <2 years and those with AD-onset time ≥2 years. After adjustment for age, gender, and parental allergic history, serum periostin level (OR: 1.03, 95% CI: 1.00-1.06, P=.046) contributed to the development of AD in children with AD-onset time <2 years. CONCLUSION: Serum periostin level may play a role in the severity and chronicity of AD in children.
BACKGROUND: Serum periostin might be a biomarker in the pathogenesis of T helper 2-type allergic diseases. The aim of this study was to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis (AD) in children. METHODS: This population-based study examined 4076 children aged 4 to 13 years between June 2015 and July 2015. Of the 4076 children, 196-137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control (HC) group-were included for the final analysis. RESULTS: Serum periostin levels were higher in the AD group than in the HC group (P<.001) and were found to be positively associated with SCORAD score (Spearman's rho [r]=.24, P=.001). Children with AD-onset time <2 years had significantly higher periostin levels (P=.030) compared to those with AD-onset time ≥2 years. The total eosinophil (P=.189) and IgE levels (P=.140) were comparable between children with AD-onset time <2 years and those with AD-onset time ≥2 years. After adjustment for age, gender, and parental allergic history, serum periostin level (OR: 1.03, 95% CI: 1.00-1.06, P=.046) contributed to the development of AD in children with AD-onset time <2 years. CONCLUSION: Serum periostin level may play a role in the severity and chronicity of AD in children.
Authors: Myongsoon Sung; Dong Keon Yon; Seung Won Lee; Ju Hee Kim; Hey Sung Baek; Hye Mi Jee; Youn Ho Shin; Man Yong Han Journal: Biomed Res Int Date: 2021-11-18 Impact factor: 3.411