Sensen Su1, Wanning Wang1, Tao Sun1, Fuzhe Ma1, Yue Wang1, Jia Li1, Zhonggao Xu2. 1. Department of Nephrology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, Jilin Province, China. 2. Department of Nephrology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, Jilin Province, China. zhong62342645@163.com.
Abstract
BACKGROUND: Previous studies have investigated the connection between diabetic nephropathy and smoking, and reported widely varying rates. This study aimed to systematically analyze the impact of smoking on diabetic nephropathy. METHODS: We searched the PubMed and EMBASE electronic databases to identify relevant English-language studies published up to March 2016. Eligible studies were selected using inclusion and exclusion criteria. Data for each study were extracted independently by two authors. The homogeneity of the effect size across the studies was tested. Odds ratio (OR) was calculated by using the random-effect model. Sensitivity analysis was performed to reduce heterogeneity, and publication biases were examined. RESULTS: A total of 21 eligible studies were selected and pooled analyzed. No significant differences in demographic characteristics were found between patients with diabetic nephropathy and those with non-diabetic nephropathy. Significant heterogeneity across studies was found except those of diabetes mellitus controls. The aggregate OR of smoking in the patients with diabetic nephropathy in comparison with those with non-diabetic nephropathy was 1.70 (95% confidence interval 1.48-1.95). No evidence of publication bias was found. CONCLUSION: Our findings indicate that smoking is a significant risk factor for diabetic nephropathy in diabetic patients.
BACKGROUND: Previous studies have investigated the connection between diabetic nephropathy and smoking, and reported widely varying rates. This study aimed to systematically analyze the impact of smoking on diabetic nephropathy. METHODS: We searched the PubMed and EMBASE electronic databases to identify relevant English-language studies published up to March 2016. Eligible studies were selected using inclusion and exclusion criteria. Data for each study were extracted independently by two authors. The homogeneity of the effect size across the studies was tested. Odds ratio (OR) was calculated by using the random-effect model. Sensitivity analysis was performed to reduce heterogeneity, and publication biases were examined. RESULTS: A total of 21 eligible studies were selected and pooled analyzed. No significant differences in demographic characteristics were found between patients with diabetic nephropathy and those with non-diabetic nephropathy. Significant heterogeneity across studies was found except those of diabetes mellitus controls. The aggregate OR of smoking in the patients with diabetic nephropathy in comparison with those with non-diabetic nephropathy was 1.70 (95% confidence interval 1.48-1.95). No evidence of publication bias was found. CONCLUSION: Our findings indicate that smoking is a significant risk factor for diabetic nephropathy in diabeticpatients.
Authors: Risa Ozaki; Kitty K T Cheung; Enoch Wu; Alice Kong; Xilin Yang; Eric Lau; Philippe Brunswick; Jean-Henri Calvet; Jean-Paul Deslypere; Juliana C N Chan Journal: Diabetes Technol Ther Date: 2011-06-29 Impact factor: 6.118
Authors: Yashpal S Kanwar; Jun Wada; Lin Sun; Ping Xie; Elisabeth I Wallner; Sheldon Chen; Sumant Chugh; Farhad R Danesh Journal: Exp Biol Med (Maywood) Date: 2008-01
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