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Literature DB >> 28631040

Biomarkers to detect rejection after kidney transplantation.

Abstract

Detecting acute rejection in kidney transplantation has been traditionally done using histological analysis of invasive allograft biopsies, but this method carries a risk and is not perfect. Transplant professionals have been working to develop more accurate or less invasive biomarkers that can predict acute rejection or subsequent worse allograft survival. These biomarkers can use tissue, blood or urine as a source. They can comprise individual molecules or panels, singly or in combination, across different components or pathways of the immune system. This review highlights the most recent evidence for biomarker efficacy, especially from multicenter trials.

Keywords: Allograft loss; Biomarkers; Kidney; Pediatrics; Rejection; Transplant

Mesh：

Substances：
Biomarkers

Year: 2017 PMID： 28631040 DOI： 10.1007/s00467-017-3712-6

Source DB: PubMed Journal: Pediatr Nephrol ISSN： 0931-041X Impact factor: 3.714

75 in total

1. High CXCL10 expression in rejected kidneys and predictive role of pretransplant serum CXCL10 for acute rejection and chronic allograft nephropathy.

Authors: Elena Lazzeri; Mario Rotondi; Benedetta Mazzinghi; Laura Lasagni; Andrea Buonamano; Alberto Rosati; Fabio Pradella; Vittorio Fossombroni; Giorgio La Villa; Mauro Gacci; Elisabetta Bertoni; Mario Serio; Maurizio Salvadori; Paola Romagnani
Journal: Transplantation Date: 2005-05-15 Impact factor: 4.939

2. Messenger RNA for FOXP3 in the urine of renal-allograft recipients.

Authors: Thangamani Muthukumar; Darshana Dadhania; Ruchuang Ding; Catherine Snopkowski; Rubina Naqvi; Jun B Lee; Choli Hartono; Baogui Li; Vijay K Sharma; Surya V Seshan; Sandip Kapur; Wayne W Hancock; Joseph E Schwartz; Manikkam Suthanthiran
Journal: N Engl J Med Date: 2005-12-01 Impact factor: 91.245

3. Molecular correlates of scarring in kidney transplants: the emergence of mast cell transcripts.

Authors: M Mengel; J Reeve; S Bunnag; G Einecke; B Sis; T Mueller; B Kaplan; P F Halloran
Journal: Am J Transplant Date: 2008-10-31 Impact factor: 8.086

4. Assessing Antibody Strength: Comparison of MFI, C1q, and Titer Information.

Authors: A R Tambur; N D Herrera; K M K Haarberg; M F Cusick; R A Gordon; J R Leventhal; J J Friedewald; D Glotz
Journal: Am J Transplant Date: 2015-04-30 Impact factor: 8.086

5. Presence of donor-specific DNA in plasma of kidney and liver-transplant recipients.

Authors: Y M Lo; M S Tein; C C Pang; C K Yeung; K L Tong; N M Hjelm
Journal: Lancet Date: 1998-05-02 Impact factor: 79.321

6. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management.

Authors: Richard Kowalski; Diane Post; Mary C Schneider; Judith Britz; Judy Thomas; Mark Deierhoi; Andrew Lobashevsky; Robert Redfield; Eugene Schweitzer; Alonso Heredia; Elise Reardon; Charles Davis; Carol Bentlejewski; John Fung; Ron Shapiro; Adriana Zeevi
Journal: Clin Transplant Date: 2003-04 Impact factor: 2.863

7. Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.

Authors: Vikas R Dharnidharka; Eihab Al Khasawneh; Sushil Gupta; Jonathan J Shuster; Douglas W Theriaque; Amir H Shahlaee; Timothy J Garrett
Journal: Transplantation Date: 2013-09 Impact factor: 4.939

8. Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes.

Authors: B D Modena; S M Kurian; L W Gaber; J Waalen; A I Su; T Gelbart; T S Mondala; S R Head; S Papp; R Heilman; J J Friedewald; S M Flechner; C L Marsh; R S Sung; H Shidban; L Chan; M M Abecassis; D R Salomon
Journal: Am J Transplant Date: 2016-03-15 Impact factor: 8.086

9. Complement-binding anti-HLA antibodies and kidney-allograft survival.

Authors: Alexandre Loupy; Carmen Lefaucheur; Dewi Vernerey; Christof Prugger; Jean-Paul Duong van Huyen; Nuala Mooney; Caroline Suberbielle; Véronique Frémeaux-Bacchi; Arnaud Méjean; François Desgrandchamps; Dany Anglicheau; Dominique Nochy; Dominique Charron; Jean-Philippe Empana; Michel Delahousse; Christophe Legendre; Denis Glotz; Gary S Hill; Adriana Zeevi; Xavier Jouven
Journal: N Engl J Med Date: 2013-09-26 Impact factor: 91.245

10. Anti-human leukocyte antigen and donor-specific antibodies detected by luminex posttransplant serve as biomarkers for chronic rejection of renal allografts.

Authors: Nils Lachmann; Paul I Terasaki; Klemens Budde; Lutz Liefeldt; Andreas Kahl; Petra Reinke; Johann Pratschke; Birgit Rudolph; Danilo Schmidt; Abdulgabar Salama; Constanze Schönemann
Journal: Transplantation Date: 2009-05-27 Impact factor: 4.939

6 in total

Biomarkers to detect rejection after kidney transplantation.

1. High CXCL10 expression in rejected kidneys and predictive role of pretransplant serum CXCL10 for acute rejection and chronic allograft nephropathy.

2. Messenger RNA for FOXP3 in the urine of renal-allograft recipients.

3. Molecular correlates of scarring in kidney transplants: the emergence of mast cell transcripts.

4. Assessing Antibody Strength: Comparison of MFI, C1q, and Titer Information.

5. Presence of donor-specific DNA in plasma of kidney and liver-transplant recipients.

6. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management.

7. Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.

8. Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes.

9. Complement-binding anti-HLA antibodies and kidney-allograft survival.

10. Anti-human leukocyte antigen and donor-specific antibodies detected by luminex posttransplant serve as biomarkers for chronic rejection of renal allografts.

Review 1. Single-cell Transcriptomics and Solid Organ Transplantation.

Review 2. Molecular Markers of Kidney Transplantation Outcome: Current Omics Tools and Future Developments.

Review 3. Emerging monitoring technologies in kidney transplantation.

Review 4. Therapies for Chronic Allograft Rejection.

Review 5. Challenges of Diagnosing Antibody-Mediated Rejection: The Role of Invasive and Non-Invasive Biomarkers.

Review 6. New Insights from Metabolomics in Pediatric Renal Diseases.