Brian I Carr1, Vito Guerra2. 1. Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey. brianicarr@hotmail.com. 2. Department of Clinical Trials, IRCCS de Bellis, Castellana Grotte, Italy.
Abstract
BACKGROUND: We recently constructed a liver index (LI) from four liver parameters, namely: blood total bilirubin, gamma glutamyl transpeptidase (GGTP), albumin, and platelet levels (a cirrhosis surrogate). We found that the scores for the liver index related significantly to a four-parameter HCC aggressiveness index (maximum tumor diameter, multifocality, percent portal vein invasion, and blood AFP levels). AIMS: To validate the relationship of liver parameters to tumor aggressiveness parameters in a larger, different HCC dataset. RESULTS: We now confirm these associations in another large HCC cohort. Furthermore, this liver index showed significant trends with the individual HCC aggressiveness parameters. CONCLUSIONS: These results provide further support for the idea that liver microenvironment, as reflected in liver function tests, may relate to HCC behavior.
BACKGROUND: We recently constructed a liver index (LI) from four liver parameters, namely: blood total bilirubin, gamma glutamyl transpeptidase (GGTP), albumin, and platelet levels (a cirrhosis surrogate). We found that the scores for the liver index related significantly to a four-parameter HCC aggressiveness index (maximum tumor diameter, multifocality, percent portal vein invasion, and blood AFP levels). AIMS: To validate the relationship of liver parameters to tumor aggressiveness parameters in a larger, different HCC dataset. RESULTS: We now confirm these associations in another large HCC cohort. Furthermore, this liver index showed significant trends with the individual HCC aggressiveness parameters. CONCLUSIONS: These results provide further support for the idea that liver microenvironment, as reflected in liver function tests, may relate to HCC behavior.
Entities:
Keywords:
Aggressiveness index; HCC parameters; Liver function
Authors: Khairuddin Memon; Laura M Kulik; Robert J Lewandowski; Edward Wang; Jonathan Wang; Robert K Ryu; Ryan Hickey; Michael Vouche; Talia Baker; Daniel Ganger; Vanessa L Gates; Ali Habib; Mary F Mulcahy; Riad Salem Journal: J Vasc Interv Radiol Date: 2014-03-07 Impact factor: 3.464
Authors: Brian I Carr; Vito Guerra; Edoardo G Giannini; Fabio Farinati; Francesca Ciccarese; Gian Ludovico Rapaccini; Maria Di Marco; Luisa Benvegnù; Marco Zoli; Franco Borzio; Eugenio Caturelli; Maria Chiaramonte; Franco Trevisani Journal: Semin Oncol Date: 2014-03-06 Impact factor: 4.929
Authors: Brian I Carr; Vito Guerra; Edoardo G Giannini; Fabio Farinati; Francesca Ciccarese; Gian Ludovico Rapaccini; Maria Di Marco; Luisa Benvegnù; Marco Zoli; Franco Borzio; Eugenio Caturelli; Alberto Masotto; Franco Trevisani Journal: J Integr Oncol Date: 2016-09-05