Literature DB >> 2863055

The effects of calcitonin, parathyroid hormone and prostaglandin E2 on cyclic AMP levels of isolated osteoclasts.

M B Ito, H Schraer, C V Gay.   

Abstract

Cyclic AMP (cAMP) levels were measured in both isolated and attached osteoclasts. The level of cAMP was 0.1 pmol/10(5) osteoclasts. No change in cAMP level of osteoclasts could be detected following calcitonin treatment. Parathyroid hormone (PTH) and prostaglandin E2 (PGE2) treatment stimulated cAMP production in proportion to alkaline phosphatase levels and divergent to acid phosphatase levels. This indicates that osteoblasts, not osteoclasts, were responsive to PTH and PGE2.

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Year:  1985        PMID: 2863055     DOI: 10.1016/0300-9629(85)91043-6

Source DB:  PubMed          Journal:  Comp Biochem Physiol A Comp Physiol        ISSN: 0300-9629


  2 in total

1.  Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

Authors:  G C Nicholson; J M Moseley; P M Sexton; F A Mendelsohn; T J Martin
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

Review 2.  Peptides from the calcitonin genes: molecular genetics, structure and function.

Authors:  L H Breimer; I MacIntyre; M Zaidi
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

  2 in total

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