Dose-Finding Methods: Moving Away from the 3 + 3 to Include Richer Outcomes.

The most commonly used method for dose finding, the 3 + 3, has poor performance. New adaptive designs are more efficient. Nevertheless, they have reached a maximum performance level, and further improvement requires either larger sample sizes or outcomes measures richer than the simplistic severe toxicity measured at cycle 1. Clin Cancer Res; 23(15); 3977-9. ©2017 AACRSee related article by Yan et al., p. 3994. ©2017 American Association for Cancer Research.