Literature DB >> 28630196

Antimicrobial Susceptibility Trends among Staphylococcus aureus Isolates from U.S. Hospitals: Results from 7 Years of the Ceftaroline (AWARE) Surveillance Program, 2010 to 2016.

Helio S Sader1, Rodrigo E Mendes2, Jennifer M Streit2, Robert K Flamm2.   

Abstract

We evaluated trends in Staphylococcus aureus antimicrobial susceptibility in U.S. hospitals in the 2010-2016 period. A total of 21,056 clinical isolates from 42 medical centers were tested for susceptibility by broth microdilution methods. Methicillin-resistant S. aureus (MRSA) rates decreased from 50.0% (in 2010) to 42.2% (in 2016). Susceptibility to erythromycin, levofloxacin, and clindamycin increased slightly, whereas susceptibility to ceftaroline, trimethoprim-sulfamethoxazole, and tetracycline remained stable. Ceftaroline retained potent activity against methicillin-susceptible S. aureus (MSSA) and MRSA (97.2% susceptible) with no marked variations.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  MRSA; ceftaroline; cephalosporin; methicillin-resistant Staphylococcus aureus; skin and skin structure infection

Mesh:

Substances:

Year:  2017        PMID: 28630196      PMCID: PMC5571371          DOI: 10.1128/AAC.01043-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  16 in total

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Review 2.  Ceftaroline fosamil: a review of its use in the treatment of complicated skin and soft tissue infections and community-acquired pneumonia.

Authors:  James E Frampton
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Authors:  Helio S Sader; David J Farrell; Rodrigo E Mendes; Robert K Flamm; Mariana Castanheira; Ronald N Jones
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Review 5.  Life After USA300: The Rise and Fall of a Superbug.

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Journal:  Pediatr Infect Dis J       Date:  2014-08       Impact factor: 2.129

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Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

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Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191

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9.  The use of extrapolation based on modeling and simulation to support high-dose regimens of ceftaroline fosamil in pediatric patients with complicated skin and soft-tissue infections.

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10.  Genomic Update of Phenotypic Prediction Rule for Methicillin-Resistant Staphylococcus aureus (MRSA) USA300 Discloses Jail Transmission Networks with Increased Resistance.

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