Literature DB >> 28630179

Antibiotic Resistance as a Stress Response: Recovery of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus "Auxiliary" (fem) Mutants by Induction of the Stringent Stress Response.

Choon Keun Kim1, Catarina Milheiriço1,2, Hermínia de Lencastre1,2, Alexander Tomasz3.   

Abstract

Studies with methicillin-resistant Staphylococcus aureus (MRSA) strain COL have shown that the optimal resistance phenotype requires not only mecA but also a large number of "auxiliary genes" identified by Tn551 mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-MICs of mupirocin, suggesting that the mechanism of reduced resistance in the auxiliary mutants involved the interruption of a stringent stress response, causing reduced production of penicillin-binding protein 2A (PBP 2A).
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  auxiliary genes; oxacillin resistance expression; stress response

Mesh：

Substances：

Year:  2017        PMID： 28630179      PMCID： PMC5527599          DOI： 10.1128/AAC.00313-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

1.  Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA).

Authors:  K Hiramatsu; K Asada; E Suzuki; K Okonogi; T Yokota
Journal:  FEBS Lett       Date:  1992-02-24       Impact factor: 4.124

2.  Investigations into sigmaB-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus.

Authors:  Lindsey N Shaw; Joanne Aish; Jessica E Davenport; Melanie C Brown; James K Lithgow; Kay Simmonite; Howard Crossley; James Travis; Jan Potempa; Simon J Foster
Journal:  J Bacteriol       Date:  2006-09       Impact factor: 3.490

3.  Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus.

Authors:  Melanie R Stapleton; Malcolm J Horsburgh; Emma J Hayhurst; Lynda Wright; Ing-Marie Jonsson; Andrej Tarkowski; John F Kokai-Kun; James J Mond; Simon J Foster
Journal:  J Bacteriol       Date:  2007-08-03       Impact factor: 3.490

Review 4.  Auxiliary factors: a chink in the armor of MRSA resistance to β-lactam antibiotics.

Authors:  Terry Roemer; Tanja Schneider; Mariana G Pinho
Journal:  Curr Opin Microbiol       Date:  2013-07-26       Impact factor: 7.934

5.  Conversion of a homogeneously methicillin-resistant strain of Staphylococcus aureus to heterogeneous resistance by Tn551-mediated insertional inactivation.

Authors:  J Kornblum; B J Hartman; R P Novick; A Tomasz
Journal:  Eur J Clin Microbiol       Date:  1986-12       Impact factor: 3.267

6.  Beta-lactam-specific resistant mutants of Staphylococcus aureus.

Authors:  E Tonin; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1986-10       Impact factor: 5.191

7.  Development of methicillin resistance in clinical isolates of Staphylococcus sciuri by transcriptional activation of the mecA homologue native to s.

Authors:  Isabel Couto; Shang Wei Wu; Alexander Tomasz; Hermínia de Lencastre
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

8.  Impact of sigB mutation on Staphylococcus aureus oxacillin and vancomycin resistance varies with parental background and method of assessment.

Authors:  Vineet K Singh; Jennifer L Schmidt; R K Jayaswal; Brian J Wilkinson
Journal:  Int J Antimicrob Agents       Date:  2003-03       Impact factor: 5.283

9.  Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.

Authors:  Laura García-Álvarez; Matthew T G Holden; Heather Lindsay; Cerian R Webb; Derek F J Brown; Martin D Curran; Enid Walpole; Karen Brooks; Derek J Pickard; Christopher Teale; Julian Parkhill; Stephen D Bentley; Giles F Edwards; E Kirsty Girvan; Angela M Kearns; Bruno Pichon; Robert L R Hill; Anders Rhod Larsen; Robert L Skov; Sharon J Peacock; Duncan J Maskell; Mark A Holmes
Journal:  Lancet Infect Dis       Date:  2011-08       Impact factor: 25.071

10.  Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci.

Authors:  Joana Rolo; Peder Worning; Jesper Boye Nielsen; Rita Sobral; Rory Bowden; Ons Bouchami; Peter Damborg; Luca Guardabassi; Vincent Perreten; Henrik Westh; Alexander Tomasz; Hermínia de Lencastre; Maria Miragaia
Journal:  PLoS Genet       Date:  2017-04-10       Impact factor: 5.917
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  8 in total

1.  Genetic Determinants of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus.

Authors:  Maria Pardos de la Gandara; Vitor Borges; Marilyn Chung; Catarina Milheiriço; João Paulo Gomes; Herminia de Lencastre; Alexander Tomasz
Journal:  Antimicrob Agents Chemother       Date:  2018-05-25       Impact factor: 5.191

2.  Impact of the Stringent Stress Response on the Expression of Methicillin Resistance in Staphylococcaceae Strains Carrying mecA, mecA1 and mecC.

Authors:  Catarina Milheiriço; Alexander Tomasz; Hermínia de Lencastre
Journal:  Antibiotics (Basel)       Date:  2022-02-16

Review 3.  Antimicrobial resistance in methicillin-resistant Staphylococcus aureus to newer antimicrobial agents.

Authors:  Richard R Watkins; Marisa Holubar; Michael Z David
Journal:  Antimicrob Agents Chemother       Date:  2019-09-16       Impact factor: 5.191

4.  Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections.

Authors:  Stefano G Giulieri; Steven Y C Tong; Deborah A Williamson
Journal:  Microb Genom       Date:  2020-01

5.  Ftsh Sensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics by Degrading YpfP, a Lipoteichoic Acid Synthesis Enzyme.

Authors:  Won-Sik Yeo; Bohyun Jeong; Nimat Ullah; Majid Ali Shah; Amjad Ali; Kyeong Kyu Kim; Taeok Bae
Journal:  Antibiotics (Basel)       Date:  2021-10-01

Review 6.  Microbial resistance to nanotechnologies: An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants.

Authors:  Zhuoran Wu; Brian Chan; Jessalyn Low; Justin Jang Hann Chu; Hwee Weng Dennis Hey; Andy Tay
Journal:  Bioact Mater       Date:  2022-03-03

7.  Genomic and Therapeutic Analyses of Staphylococcus aureus Isolated from Cattle Reproductive Tract.

Authors:  Laiba Shafique; Amjad Islam Aqib; Qin Liang; Chaobin Qin; Muhammad Muddassir Ali; Memoona Adil; Zaeem Sarwar; Arslan Saleem; Muhammad Ajmal; Alveena Khan; Hongping Pan; Kuiqing Cui; Qingyou Liu
Journal:  Biomed Res Int       Date:  2022-09-13       Impact factor: 3.246

8.  Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility.

Authors:  Anissa D Scholtzek; Dennis Hanke; Birgit Walther; Inga Eichhorn; Sabita D Stöckle; Katja-Sophia Klein; Heidrun Gehlen; Antina Lübke-Becker; Stefan Schwarz; Andrea T Feßler
Journal:  Toxins (Basel)       Date:  2019-09-13       Impact factor: 4.546
  8 in total

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